RESUMO
Acetone extract of Peucedanum nebrodense (Guss.) Strohl., a rare endemic species from the Madonie mountains (Sicily), was tested in vitro for its antimicrobial activity against bacterial reference strains and antiproliferative activity against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and L1210 (murine leukemia) cell lines. The acetone extract showed antiproliferative IC50 values in the range of 14-0.27 microg/ml.
Assuntos
Anti-Infecciosos/farmacologia , Antineoplásicos/farmacologia , Apiaceae/química , Acetona , Animais , Divisão Celular/efeitos dos fármacos , Células HL-60 , Humanos , Células K562 , Leucemia L1210 , Camundongos , Componentes Aéreos da Planta/química , Extratos Vegetais/farmacologia , Raízes de Plantas/químicaRESUMO
Two new sesquiterpene lactones: 8alpha-(4'-acetoxymethacryloyloxy)-3alpha,9beta-dihydroxy-1(10)E,4Z,11(13)-germacratrien-12,6alpha-olide (1) and 8alpha-(2'E)-(2'-acetoxymethyl-2'-butenoyloxy)-3alpha,9beta-dihydroxy-1(10)E,4Z,11(13)-germacratrien-12,6alphaolide (2), together with the known zoapatanolide A were isolated from the aerial parts of Montanoa tomentosa Cerv. in La Llave et Lex ssp. microcephala (Sch. Bip. In K. Koch) V.A. Funk (Asteraceae). The structures of all compounds were established on the basis of 1D, 2D NMR, and EIMS analysis.
Assuntos
Asteraceae/química , Lactonas/isolamento & purificação , Oxepinas/isolamento & purificação , Sesquiterpenos de Germacrano , Sesquiterpenos/isolamento & purificação , Abortivos não Esteroides/química , Abortivos não Esteroides/isolamento & purificação , Feminino , Humanos , Lactonas/química , Espectroscopia de Ressonância Magnética , Medicina Tradicional , México , Estrutura Molecular , Montanoa , Oxepinas/química , Sesquiterpenos/químicaRESUMO
Five new bisdesmosidic saponins (1--5) were isolated from the aerial parts of Tupidanthus calyptratus. Their structures were determined by (1)H--(1)H correlation spectroscopy (COSY, TOCSY, ROESY) and (1)H--(13)C correlation (HSQC, HMBC) NMR experiments, FABMS, and chemical data.
