[The levels of resistin and other adipokines in patients with hypothyroidism].

AIM: To investigate the relationship of resistin, adiponectin, leptin, and hormone metabolic parameters in patients with hypothyroidism. SUBJECTS AND METHODS: Ninety-three women aged 58.0 (53.0-63.0) years with hypothyroidism were examined. A control group consisted of 10 women aged 48 (47-50) years. Anthropometric characteristics, glucose and lipid metabolic parameters, and leptin, resistin, adiponectin levels were studied. RESULTS: The patients with hypothyroidism were found to have statistically significantly enhanced insulin resistance (IR) and compensatory hyperinsulinemia in the presence of android fat distribution. The found atherogenic dyslipidemia manifested itself as an increase in the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and atherogenic index and as a reduction in high-density lipoprotein cholesterol. The concentration of leptin and resistin was increased and that of adiponectin was reduced in the patients with hypothyroidism. There was a correlation of leptin and adiponectin with fat metabolic parameters. CONCLUSION: The women with hypothyroidism had enhanced IR, as well as compensatory hyperinsulinemia in the presence of android fat distribution. Hypothyroidism is accompanied by the development of atherogenic dyslipidemia. The concentration of leptin and resistin was elevated and that of adiponectin was reduced in the examinees.

[Pathogenesis of arterial hypertension in puberal juvenile dyspituitarism]. / Nekotorye aspekty patogeneza arterial'noi gipertonii pri pubertatno-iunosheskom dispituitarizme.

Pubertal juvenile dyspituitarism (PJD) is one of the common types of obesity in adolescents. Literature data on the involvement of the renin-angiotensin-aldosterone, hypophysis-adrenal cortex system in the formation of this syndrome are of controversial nature, and the pathogenesis of the development of arterial hypertension in PJD is obscure in many respects. The purpose of the study was to investigate the activity of plasma renin, potassium and sodium in the blood serum as well as the excretion of potassium and sodium with daily urine in PJD patients. A total of 148 PJD patients aged 14 to 21 were examined, of them 22 had exogenous constitutional obesity. The control group was composed of 54 healthy persons of the same sex and age. Electrolyte metabolic derangement, an increase in the ACTH level and hyperaldosteronemia were shown to play a certain role in the development of arterial hypertension in PJD. The above changes developed in the presence of disordered interrelationships in the hypophysis-adrenal cortex, renin-angiotensin-aldosterone system.

[Pharmcodynamic evaluation of the use of anaprilin combined with merkazolil for the therapy of thyrotoxicosis]. / Farmakodinamicheskaia otsenka primeneniia anaprilina v sochetanii s merkazolilom dlia terapii tireotoksikoza.

Anaprilin pharmacodynamics was studied in thyrotoxicosis patients. The clinical therapeutic effect of anaprilin, mercazolyl and their combinations was studied. In anaprilin therapy the drug should be individually dosed out with regard to its basal concentration in the blood and the degree of pulse retardation at rest. An adequate anaprilin dose for most patients was 160 mg/day. Anaprilin-mercazolyl combined therapy resulted in more retarded pulse as compared to a single drug therapy with anaprilin. The effect of anaprilin was potentiated by mercazolyl doses which did not by themselves cause a positive cardiovascular effect in the first two weeks of therapy.

[Characteristics of the course of hypertension in relation to on plasma renin activity]. / Osobennosti techeniia gipertonicheskoi bolezni v zavisimosti ot aktivnosti renina v plazme krovi.

In 94 patients with hypertension the plasma renin activity was determined by the Yu. A. Serebrovskaya and I.A. Uchitel technique, the glomerular filtration--after Rehberg, potassium and sodium content in blood serum and 24-hour urine samples--by flame photometry. Hypertensive disease was found to be accompanied by an elevated plasma renin activity in 47.9% of the patients, by a normal level--in 26.9%, and by a reduced--in 25.6%, as compared with control group data. Cardiovascular complicatins were found in 1/5 of those with an elevated plasma renin activity, and no such complications were observed in those with a normal or reduced renin activity. An elevated plasma renin activity is a risk factor. The highest mean age and the longest duration of the disease history are typical for patients with low plasma renin activity. To choose the most rational therapy regimen it may be useful to calculate the renin-sodium index that reflects the relationship between the plasma renin activity and the urine excretion of sodium.