RESUMO
BACKGROUND: Elective caesarean section is performed mainly under spinal anaesthesia using hyperbaric bupivacaine combined with opioids. Despite rapid onset, good quality anaesthesia, bupivacaine provides a long duration of motor block and is related to maternal hypotension. Current policies appeal for implementation of enhanced recovery procedures after caesarean section. Hyperbaric prilocaine is an intermediate-acting local anaesthetic known for its efficacy in ambulatory surgery. Evidence on the clinical relevance of intrathecal prilocaine use for caesarean section is currently lacking. OBJECTIVES: We aimed to investigate whether hyperbaric prilocaine would offer a shorter motor block and recovery than bupivacaine, when comparing equipotent doses. We also assessed the characteristics of sensory block, maternal haemodynamics and side effects for both mother and newborn. DESIGN: Prospective, randomised, double-blind, controlled, two-centre, clinical trial. SETTING: One university teaching hospital and one general teaching hospital in Brussels, Belgium. PATIENTS: American Society of Anesthesiologists' physical status 2 parturients (nâ=â40) undergoing caesarean section under spinal anaesthesia. INTERVENTIONS: Patients were randomly assigned to receive spinal anaesthesia using hyperbaric prilocaine 50âmg or hyperbaric bupivacaine 10âmg, both given with sufentanil 2.5âµg and morphine 100âµg. An epidural catheter was introduced as a backup in case of failure. MAIN OUTCOMES: The primary outcome was the motor block regression (modified Bromage scale 1 to 6). Secondary outcomes included sensory block characteristics, first unassisted ambulation, maternal side effects, newborns' parameters and overall satisfaction. RESULTS: Median [IQR] motor block was significantly shorter in the hyperbaric prilocaine group (110 [104 to 150] min versus 175 [135 to 189] min, Pâ=â0.001). First unassisted ambulation was achieved earlier after prilocaine (204.5 [177 to 246.5] min versus 314 [209.25 to 400] min, Pâ=â0.007), and the incidence of maternal hypotension was significantly higher with bupivacaine (Pâ=â0.033). No supplementary epidural analgesia was needed. CONCLUSION: Prilocaine provides shorter motor block, faster recovery and better haemodynamic stability than bupivacaine while offering equivalent surgical anaesthesia. TRIAL REGISTRATION: Clinicaltrials.gov: NCT02973048, EudraCT: 2016-003010-26.
Assuntos
Anestesia Obstétrica , Raquianestesia , Anestesia Obstétrica/efeitos adversos , Raquianestesia/efeitos adversos , Anestésicos Locais/efeitos adversos , Bupivacaína/efeitos adversos , Cesárea , Método Duplo-Cego , Feminino , Humanos , Recém-Nascido , Gravidez , Prilocaína , Estudos ProspectivosRESUMO
Acute fatty liver of pregnancy (AFLP) is a rare but dramatic condition associated with a high maternal and fetal morbidity and mortality. We present a short review of AFLP management, illustrated by a case report. We conducted a systematic literature search for 'acute fatty liver of pregnancy', concerning its management. We found initially 11 studies, and three of them met the selection criteria. Prompt diagnosis, maternal stabilisation and rapid delivery are mandatory. This illustrative AFLP case fulfilled nine out of 14 Swansea criteria. Caesarean section is often required (as illustrated in this case), reducing maternal and perinatal mortality rates.