Hypoacusia in a patient treated by isotretinoin.

Isotretinoin is the most effective treatment for severe acne, but there are several adverse effects associated with its use, some of them very exceptional (<1/10000). We report one case of hypoacusia and tinnitus in a 15-year-old boy treated with isotretinoin during 6 weeks, who quickly improved after isotretinoin withdrawal. Also, we comment other publications about hearing alterations in patients treated with isotretinoin and other retinoids.

[Pancreatic panniculitis. Report of a case and review of literature]. / Presentación de un caso de paniculitis pancreática y revisión de la bibliografía.

Pancreatic panniculitis is an uncommon complication of pancreatic disease, which is characterized by liquefactive necrosis of the subcutaneous fat and may constitute the first evidence of a pancreatic illness. Herein, we report a case where cutaneous lesions of pancreatic disease were recognized prior to detection of an acute episode of a known chronic pancreatitis.