1.
NIDA Res Monogr
; 67: 73-81, 1986.
Artigo
em Inglês
| MEDLINE
| ID: mdl-3092100
2.
J Anal Toxicol
; 6(6): 294-6, 1982.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7162139
RESUMO
Published gas-liquid chromatographic (GLC) methods for the determination of nicotine and cotinine have proved impractical for the analysis of a large number of clinical samples. Significant improvements over other methods have been achieved, being low sample volume (0.5 mL plasma), rapid two-step extraction from plasma, no evaporation step, and good separation. The lower limits of sensitivity for nicotine and cotinine were 1 and 5 ng/mL, respectively. The method was validated by the analysis of plasma samples from cigarette-smoking volunteers. The method described permits the quick, routine determination of nicotine and cotinine in a large number of samples.
Assuntos
Cotinina/sangue , Nicotina/sangue , Pirrolidinonas/sangue , Cromatografia Gasosa , Humanos , Fumar
3.
Anal Chem
; 49(13): 1965-9, 1977 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-907157