[Determining the degree of risk of postoperative complications in patients with a benign tumor of the parotid salivary gland]. / Opredelenie stepeni riska vozniknoveniya posleoperatsionnykh oslozhnenii u patsientov s dobrokachestvennoi opukhol'yu okoloushnoi slyunnoi zhelezy.

THE AIM OF THE STUDY: Determination of the risk of postoperative complications in patients after surgical treatment of benign neoplasms of the parotid salivary glands. MATERIAL AND METHODS: The results of treatment of 228 patients with benign neoplasms of the parotid salivary gland in the period from 2019 to 2021 were analyzed. A questionnaire of 7 questions was formed the answers to which allowed patients to be assigned to a certain risk group: low, medium, high or extremely high. This gradation allows choosing the optimal method and scope of surgical treatment for each patient individually. RESULTS: Patients of the first and second groups (low and medium risk) are characterized by the occurrence of temporary isolated facial nerve dysfunction with a short recovery period (up to 1 month), as well as sialocele associated with the preservation of a fragment of the gland. For the patients of the third and fourth groups (high and extremely high risk) in which parotidectomy was performed typical features included persistent paresis of facial muscles and facial soft tissue asymmetry. CONCLUSION: A personalized approach based on determining the degree of risk of postoperative complications helps surgeon in deciding on the scope of surgical treatment from subtotal resection to total parotidectomy.

[Complications in the surgery of the parotid salivary glands. Causes, mechanisms of development, methods of prevention]. / Oslozhneniya v khirurgii okoloushnykh slyunnykh zhelez. Prichiny, mekhanizmy razvitiya, sposoby profilaktiki.

Operations for neoplasms of the parotid salivary gland require from the surgeon a deep knowledge of the anatomical and topographic features of this area and technical skill, which puts it in a number of «jewelry¼ operations that require patience and concentration. The review is devoted to the topic of specific postoperative complications after parotidectomy or subtotal resection of the gland. These include relapses of tumors, paralysis or paresis of facial muscles, Frey syndrome, salivary fistulas or sialocele, violation of skin sensitivity, soft tissue deformity. The review presents the frequency and causes of complications, mechanisms of their development, methods of prevention and elimination.

Extracellular and subcellular regulation of the PI3K/Akt cassette: new mechanisms for controlling insulin and growth factor signalling.

The PI3K (phosphoinositide 3-kinase)/Akt (also called protein kinase B) signalling cassette plays a central role in the response to growth factors, particularly insulin-like molecules, and its misregulation is a characteristic feature of diabetes and many forms of human cancer. Recent molecular genetic studies initiated in the fruitfly, Drosophila melanogaster, have highlighted two new cell-type-specific mechanisms regulating PI3K/Akt signalling and its downstream effects. First, the cellular response to this cassette is modulated by several classes of cell-surface transporters and sensors, suggesting an important role for extracellular nutrients in insulin-sensitivity. Secondly, various cell types show a markedly different subcellular distribution of the activated kinase Akt, influencing the cellular functions of this molecule. These findings reveal new mechanisms by which processes such as growth, lipogenesis and insulin resistance can be differentially regulated and may suggest novel strategies for treating insulin-linked diseases.

Comparative studies of P- and hobo-element activity, fitness components and recombination parameters in two natural populations of Drosophila melanogaster in Moldova.

The genomic frequency of crossovers, fitness components, and activity of P- and hobo-transposable elements were studied in two natural populations of Drosophila melanogaster from regions with different pesticide pressure (forest and orchard populations). A significant increase in rf (recombination frequency) in the orchard population (as compared with the forest population) has been found within segments al-b, b-cn, cn-vg (chromosome 2) and for some chromosome 3 segments, th-st, st-cu, cu-sr, sr-e. None of the populations exhibited P-properties. However, the forest population showed weak hobo activity. Both populations contained probably defective hobo copies. With respect to average fitness (as estimated using a compound-autosome strain) and fecundity, the forest population was superior to the orchard one, whereas the latter had a higher locomotor activity and resistance to etherization. The difference in rf between the populations may be due to differences in their environmental conditions. Selection for pesticide resistance may favor the propagation of genotypes with higher rf, thus, possibly, ensuring release of adaptively significant genetic variation.