Integration of time as a description parameter in risk characterisation: application to methyl mercury.

Within the food risk assessment procedure, the characterisation of the risk consists in the comparison of the dietary exposure with a health based guidance value established in a previous step. One of the identified weaknesses of this comparison is that the time is not considered in the description. The aim of this paper is to describe the dietary exposure as a dynamic process determined by the accumulation phenomenon due to successive dietary intakes and by the pharmacokinetics ruling the elimination process in between intakes. Such a process belong to the category of piecewise deterministic Markov processes, which are widely used in a large variety of applications in insurance risk or in operations research, ranging from queuing systems to inventory/storage models. The inputs of the Kinetic Dietary Exposure Model are the probability distributions governing intakes and inter-intake times, as well as the half-life of the contaminant in the human body. In this paper, an application to methyl mercury is considered, with exponential distributions for both the intakes and the inter-intake times, fitted from the French national consumption survey INCA, and a fixed half-life of 6 weeks for the elimination process. Within this framework, the process settles to a steady-state after approximately 5 years. A "Kinetic Tolerable Intake" (KTI), derived from the "Provisional Tolerable Weekly Intake" (PTWI) of 1.6 microg/kg bw, is set to 14.6 microg/kg and the probability of exceeding this threshold in the long run in the French adult female population is 1.22 E-15.

Dietary exposure of children and teenagers to benzoates, sulphites, butylhydroxyanisol (BHA) and butylhydroxytoluen (BHT) in Beirut (Lebanon).

The acceptable daily intake (ADI) for a considered chemical is by definition the amount of that substance which can be ingested every day during the life time without appreciable health risk. The theoretical risk of exceeding the ADI for benzoates, sulphites, butylhydroxyanisol (BHA) and butylhydroxytoluen (BHT) has often been examined on the basis of worst case scenario. The aim of this paper is to assess the actual intake of the food additives listed above for a group of the Lebanese population (students aged between 9 and 18 years old) likely to be highly exposed to food additives through the consumption of processed foods. Dietary exposure was obtained by combining food consumption data with food additives levels determined by chemical analysis. Food products available in Lebanon and containing added benzoates, sulphites, BHA and BHT were identified. Overall 420 samples of foods and beverages were analysed. The determination of food additives residue levels was carried out according to the official methods adopted in "Lebanese Institute for agronomic research" (IRAL) on food as consumed. The acceptable daily intake (ADI) could be exceeded for sulphites and BHT by a fraction of the population, in particular within children of 9-13 years old. Among all food additive-containing foods, the highest contributors were: soft drinks to benzoates intake, nuts and canned juices to sulphites intake, bread and biscuits to BHA intake and chewing gum to BHT intake.

Some recent advances in modelling dietary exposure to ochratoxin A.

One of the key questions when assessing the exposure to contaminants is the choice of the method and the impact of this choice on the result to be compared with the toxicological reference value. This problem is particularly significant in the case of ochratoxin A (OTA) for which the use of crude estimates can provide results close to the current provisional tolerable weekly intake (PTWI). This paper compares different exposure assessment models for OTA using the same data set for food consumption (i.e. French INCA survey 1999) for the same groups of the population (i.e. adults excluding under-reporters and children 3-14 years-old) but with various ways of handling the occurrence of OTA in food. The consumption and contamination data were combined through 11 different scenarios based on parametric and non-parametric modelling and on the use of analytical results obtained on raw commodities or on foodstuffs ready-to-eat. In order to assess exposure to OTA using data on consumption of processed and composite foods it was necessary to use recipe information in order to utilize available contamination data which only exists for raw materials. The impact of such an adjustment appears to be essential to avoid an overestimation of the exposure. The impact of the other assumptions and the choice of mathematical models influence the results less but should be considered and detailed carefully in future dietary exposure assessments.

Nutritional intake of French soccer players at the clairefontaine training center.

Young, French male athletes undergoing intensive elite sports training at the National Training Centre in Clairefontaine served as the subjects (N = 180; age range: 13 to 16 years) in a 3-year dietary survey aimed at characterizing their nutritional intake in terms of energy, macronutrients, calcium, and iron. Each year, the subjects were grouped by level into 3 promotions so that 9 groups could be studied. Dietary intake data were collected each year for each subject in the 9 groups, using a 5-day food record. The results showed that their total energy intake (TEI) was insufficient for athletes (ranging from 2352 454 to 3395 396 kcal/d as opposed to the recommended range of between 3819 and 5185 kcal/d). Furthermore, their diet was unbalanced, with too great an emphasis upon fatty foods (29.1 2.8 to 34.1 3.1% TEI vs. the 20% recommended), to the detriment of carbohydrates (48.5 4.3 to 56.6 3.1% TEI vs. the 55 to 60% recommended). The calcium intake was too low in 5 of the 9 groups while, in contrast, the iron intake was satisfactory in all groups. Furthermore, during this 3-year period at the Clairefontaine Centre, the subjects significantly (p <.05) improved their calcium and iron intakes (1021 197 and 12 2 mg/d in 1996, 1299 155 and 16 2 mg/d in 1997, and 1252 184 and 17 2 mg/d in 1998). This rise in micronutrient intakes may have been due to a physiological adaptation to growth or to the positive effects of courses on nutrition given during their stay at the Centre.

Improvement of comparability of dietary intake assessment using currently available individual food consumption surveys.

BACKGROUND: Food consumption data are used for monitoring dietary indicators of health. In this context, there is a need for comparable (individual) data at the European level. The preference is to perform a pan-European survey able to generate data collected on the same basis. Until this can be realized, the existing data have to be made as comparable as possible. OBJECTIVE: To identify solutions; to make existing food consumption data from nationally representative databases more comparable. METHODS: General guidelines for the comparison of food intake data using currently available data were discussed and agreed upon in the EFCOSUM project team. RESULTS AND CONCLUSIONS: Criteria were assessed with regard to the population involved, age of the survey, method of data collection, duration of the survey, the food classification system and the food composition tbl Based on these criteria, a maximum of 15 countries could provide food consumption data that can be made comparable at the individual level for the adult population. It is recommended to make data comparable at the food level, starting with vegetables (excluding potatoes), fruits (excluding fruit juices), fish (including shellfish) and bread. Comparability of foods is only possible at the 'raw edible' ingredient level. To achieve this, a large amount of work has to be undertaken. The approach of the EFG (Euro Food Groups) system is considered to be the best compromise between the different classification systems. Comparability at the nutrient level has to wait for the availability of a European Nutrient Database, like the one that is being developed within the EPIC context.