RESUMO
BACKGROUND: Blood product transfusion has been successfully used in solid-organ transplantation to induce tolerance. Whether a similar protective effect of blood product transfusion exists in heart transplantation is controversial. OBJECTIVE: To investigate the effect of cellular blood product transfusion within 2 weeks posttransplantation on the incidence of cellular and antibody-mediated rejection. PATIENTS AND METHODS: Patients were grouped on the basis of number of blood transfusions; group 1 received no transfusions, and groups 2, 3, and 4 each received an incremental number of transfusion units. All endomyocardial biopsy samples were routinely studied using immunofluorescence in the first 12 weeks posttransplantation. RESULTS: Baseline characteristics including age, sex, body mass index, history of diabetes, donor characteristics, and pretransplantation laboratory values were similar except that group 4 had a higher rate of previous sternotomy and longer ischemic time during transplantation. Approximately 9200 endomyocardial biopsy samples composed the data. Short- and long-term freedom from the International Society for Heart & Lung Transplantation grade 3A or higher cellular rejection and from antibody-mediated rejection were comparable between groups. CONCLUSIONS: Blood transfusions within the first 2 weeks post-transplantation do not seem to confer any protective effect against posttransplantation cellular rejection or antibody- mediated rejection. Whether other unmeasured confounding factors mask their effect requires further prospective studies.
Assuntos
Transfusão de Componentes Sanguíneos/métodos , Rejeição de Enxerto/prevenção & controle , Transplante de Coração/patologia , Tolerância Imunológica/efeitos dos fármacos , Adulto , Biópsia , Feminino , Rejeição de Enxerto/epidemiologia , Rejeição de Enxerto/imunologia , Transplante de Coração-Pulmão/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Resultado do TratamentoRESUMO
Dermatoglyphic patterns and total ridge count were sutdied in 100 random selected Indian Army Personnel of mixed Indian population. They include 25 males each of controls, psoriasis, alopecia areata and vitiligo. Increase in the loops and decrease in whorls were significant in psoriasis. In alopecia areata there was significant increase in whorls and decrease in arch patterns. Radial loops and arches were completely absent on right hands.In vitiligo there were maximum ulnar loopover third and fifth digits of each hand and radial loops were completely absent over digits of left hand. No significant change was observed in total ridge count in these three dermatoses.
