RESUMO
By means of an appropriate mathematical model (Sager's 2-components-concept) a delayed spontaneous pubertal growth spurt can be demonstrated in girls with 45,X Ullrich-Turner syndrome (UTS) (n1 = 45) as well as in those with 45,X/46,XX mosaicism (n2 = 14) never treated with any growth stimulating drug. On the average, this growth spurt begins later and its extent is smaller (mean growth rate = 3.10 and 2.79 cm, respectively, in the 15th year of chronological age) than in normal girls. The delay in acute growth spurt corresponds very well to the delay of skeletal maturation in the UTS (on the average 2 to 3 years of chronological age).
Assuntos
Transtornos do Crescimento/genética , Puberdade Tardia/genética , Síndrome de Turner/genética , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Mosaicismo/genética , Análise de RegressãoRESUMO
In accordance with Nielsen & Stradiot's protocol (1987), we report on the long-term follow-up in 50 adult females with Ullrich-Turner syndrome. Attention is drawn mainly to social problems.
Assuntos
Ajustamento Social , Síndrome de Turner/psicologia , Adulto , Comparação Transcultural , Feminino , Seguimentos , Alemanha Oriental , Humanos , Relações Interpessoais , Estudos Longitudinais , Desenvolvimento Psicossexual , Puberdade/psicologia , Grupos de Autoajuda , Inquéritos e Questionários , Síndrome de Turner/genéticaRESUMO
Macrosome newborns from mothers with an insulin-bound diabetes mellitus and also from mothers with a gestational diabetes show in the cord blood nearly always insulin levels additional to increased glucose values, which, compared with the normal controls are ten-fold higher in some cases. During the first three hours of life the blood glucose values decrease extremely. To prevent central injuries, caused by stronger hypoglycaemia, the early supply of oligosaccharides by continuous gastric infusion has proved as the most careful procedure. Stronger increases of blood glucose do not occur by this method and the insulin levels show a continuous tendency to normalisation.
Assuntos
Glicemia/metabolismo , Alimentos Formulados , Insulina/sangue , Oligossacarídeos/administração & dosagem , Gravidez em Diabéticas/sangue , Adulto , Diabetes Mellitus Tipo 1/sangue , Nutrição Enteral , Feminino , Gigantismo/sangue , Humanos , Hipoglicemia/prevenção & controle , Recém-Nascido , GravidezRESUMO
Disease-specific growth curves for Turner's syndrome were calculated by means of 2nd order homogeneous differential equations with constant coefficients, taking different cytogenetical subtypes into account. Comparison of these growth curves between X-monosomic (n = 64) and 46,XX/45,X-mixoploid (n = 20) patients reveals no differences, in contrast to the commonly accepted opinion.
Assuntos
Síndrome de Turner/fisiopatologia , Estatura , Células Cultivadas , Pré-Escolar , Aberrações Cromossômicas , Transtornos Cromossômicos , Humanos , Lactente , Cariotipagem , Análise de RegressãoAssuntos
Hipotireoidismo/diagnóstico , Hipotireoidismo Congênito , Humanos , Lactente , Recém-Nascido , Fatores de TempoRESUMO
This article gives a survey of the physiology of blood coagulation in newborn infants, subdivided into the particularities of the plasmic coagulation system and the fibronolysis. Etiology, diagnosis and therapy of the consumption coagulopathy as well as the coagulopathy of production are dealed with.
