[Systemic and local humoral immunity study using the indirect immunofluorescence reaction in chronic inflammatory lung disease patients. II. Serological research results with Haemophilus influenzae autostrains and their comparison with the level of systemic antipneumococcal immunity]. / Izuchenie pri pomoshchi reaktsii nepriamoi immunofliuorestsentisii sistemnogo i mestnogo gumoral'nogo immuniteta u bol'nykh khronicheskimi vospalitel'nymi zabolevaniiami legkikh. Soobshchenie II. Rezul'taty serologicheskikh issledovanii s autoshtammami Haemophilus influenzae i ikh sopostavlenie s urovnem antipnevmokokkovogo sistemnogo immuniteta.

The indirect immunofluorescence test with the use of H. influenzae autostrains, carried out in patients with chronic bronchitis at the acute stage of the disease, did not reveal any correlation between the presence of these bacteria in the bronchial contents and systemic immune response in 26-39% of the patients. During the acute stage of chronic bronchitis a tendency towards enhancement of immune response to H. influenzae autostrains was observed. As indicated by the repeated test, this tendency was manifested by the prevalence of high antibody titers, the increase of the mean geometrical titer (p less than 0.05) reaching the dilution 1:1135 +/- 216 and the fold increase of the initial antibody level in 18.5 +/- 5.2% of the patients. 50 patients with chronic bronchitis were found to both pneumococci and H. influenzae in their bronchial contents; as indicated by the results of the indirect immunofluorescence test with the use of autostrains of these bacteria, in 18 patients (36 +/- 6.7%) equal antibody titers (+/- 1 dilution) were detected, while more than a half of serum samples (56 +/- 7%) showed the 4-fold an greater increase of th antipneumococcal antibody level, and only 4 samples proved to have the same prevalence of activity against H. influenzae.

[Pneumococcus serotypes in acute and chronic inflammatory lung disease (1978-1980)]. / Serotipy pneuvmokokka pri ostrykh i khronicheskikh vospalitel'nykh zabolevanii legkikh (1978-1980).

The comparison of the antigenic structure of the polysaccharide capsule in 342 pneumococcal strains isolated in Leningrad from the bronchial contents of patients with acute and chronic inflammatory pulmonary diseases indicated that during 1978-1980 a change in the composition of the prevailing groups of serotypes occurred every year. The comparison of the groups of prevailing pneumococcal serotypes isolated from children and adults has revealed no statistically significant differences in the specific prominence of different types, with the exception of serotype 15. Serotypes 6, 7 and 2 have been found to occur most frequently in acute pneumonia, and serotypes 23, 3, 9, 6, 15, 29 and 34 in chronic inflammatory pulmonary diseases. The preliminary data on the differences in the composition of the prevailing pneumococcal serotypes causing acute pneumonia in Leningrad and Kaunas have been obtained.

[Indirect immunofluorescence reaction study of systemic and local humoral immunity in patients with chronic inflammatory lung disease. I. Serological study results with Streptococcus pneumoniae autostrains]. / Izuchenie pri pomoshchi reaktsii nepriamoi immunofliuorestsentsii sistemnogo i mestnogo gumoral'nogo immuniteta u bol'nykh khronicheskimi vospalitel'nymi zabolevaniiami legkikh. Soobshchenie I. Rezul'taty serologicheskikh issledovanii s autoshtammami Streptococcus pneumoniae.

In the serological study of chronic bronchitis at the stage of exacerbation, carried out by means of the indirect immunofluorescence test with the use of Str. pneumoniae autostrains, 90.3 +/- 4% of the patients showed correlation between the presence of pneumococci in the bronchial contents and the systemic immunological reaction to this infective agent. At the acute stage of chronic bronchitis high antibody titers (1 : 1280 - 1 : 5120) prevailed, and the repeated study revealed the 4-fold and greater growth of the initial antibody titers in 35.7 +/- 6.4% of the patients. Antipneumococcal immunity in chronic bronchitis was found to have a pronounced type-specific character.