RESUMO
In a non-randomized study the treatment results of 59 patients with disseminated seminoma were evaluated: 21 patients were treated with a VAB-6 combination and 38 with a CP (cyclophosphamide and cisplatin) combination. After VAB-6 CR was observed in 8 patients and 6 achieved CR with additional treatment: 1 with chemotherapy (PVB) and 5 with radiotherapy (RT). The final CR rate was 67%. At a median follow-up of 38 (11-70) months 15 (71%) are alive, and 11 of them (52%) are NED; 6 have died. Of the 38 patients treated with CP alone only 18 achieved CR and 9 had a CR after additional RT and 1 chemotherapy (VAB-6), the overall CR rate was 72%. The median follow-up is 24 (4-55) months, 28 (74%) are alive, 24 (66%) are currently NED, and 9 have died. Both regimens were well tolerated, the main toxicity being leukopenia: 48% (WHO grade 111-1V-5%) for VAB-6, and 59% (13%) for CP. Hearing loss was registered in 8 patients receiving CP and in 2 receiving VAB-6. There were no fatal toxicities. Thus, VAB-6 and CP regimens seem to have compatible and high activity in disseminated seminoma.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Disgerminoma/tratamento farmacológico , Adolescente , Adulto , Bleomicina/administração & dosagem , Distribuição de Qui-Quadrado , Cisplatino/administração & dosagem , Ciclofosfamida/administração & dosagem , Dactinomicina/administração & dosagem , Disgerminoma/mortalidade , Disgerminoma/patologia , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Prognóstico , Indução de Remissão , Taxa de Sobrevida , Neoplasias Testiculares/tratamento farmacológico , Neoplasias Testiculares/mortalidade , Neoplasias Testiculares/patologia , U.R.S.S. , Vimblastina/administração & dosagemAssuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Pulmonares/secundário , Neoplasias Testiculares/tratamento farmacológico , Bleomicina/administração & dosagem , Cisplatino/administração & dosagem , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/fisiopatologia , Masculino , Indução de Remissão , Neoplasias Testiculares/fisiopatologia , Fatores de Tempo , Vimblastina/administração & dosagemRESUMO
The study was concerned with description of roentgenologic semeiotics of central and peripheral small cell lung cancer in 141 patients receiving chemoradiation therapy. The frequency of carcinoma metastasis into intrathoracic lymph nodes was high. Small cell lung cancer showed a good response to conservative treatment, which, in particular, manifested itself in regression of metastases into intrathoracic lymph nodes.
Assuntos
Carcinoma de Células Pequenas/diagnóstico por imagem , Neoplasias Pulmonares/diagnóstico por imagem , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Carcinoma de Células Pequenas/tratamento farmacológico , Carcinoma de Células Pequenas/radioterapia , Terapia Combinada , Feminino , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/radioterapia , Masculino , Pessoa de Meia-Idade , RadiografiaRESUMO
The results of surgical treatment in 260 lung cancer patients are analysed. The purposeful dynamic examination of patients by modern technics enabled a recognition of progressive tumor growth in 112 of 137 patients (81,75%) during the first 18 months after the operation. To reveal subclinical recurrences and metastases in the chest organs roentgenological and bronchological methods, positive 67Ga-citrate scintigraphy seem to be preferable. In skeletal involvement scanning findings are mostly indicative in this respect. Scanning of the organs in operable patients as a mandatory investigation is unlikely to be rational.
