RESUMO
The influence of the single components of Ferula hermonis extract on sexual behavior was studied in male rats. Sexually potent and sluggish/impotent animals were orally treated acutely (2.5 mg/kg) and subchronically (0.25 mg/kg/day for 10 days) with ferutinin, teferdin and teferin. Ferutinin alone acutely administered in potent rats was able to reduce mount and intromission latencies, while in sluggish/impotent animals, it induced the same effects and additionally shortened the ejaculation latency, as teferdin did. Both substances increased testosterone levels in rats. Unlike teferdin, ferutinin subchronically administered in potent rats negatively affected appetitive and consummatory sexual behavior, reducing also testosterone serum levels. In conclusion, if repetitively administered, ferutinin was able to stimulate sexual behavior after acute ingestion, but exerted a negative influence on the sexual capacity of potent male rats, whereas teferdin only improved copulatory performance of sluggish/impotent animals.
Assuntos
Ferula/química , Comportamento Sexual Animal/efeitos dos fármacos , Animais , Benzoatos/administração & dosagem , Compostos Bicíclicos com Pontes , Copulação/efeitos dos fármacos , Cicloeptanos , Disfunção Erétil/tratamento farmacológico , Feminino , Masculino , Ratos , Ratos Sprague-Dawley , Sesquiterpenos/administração & dosagem , Testosterona/sangue , Ácido Vanílico/administração & dosagem , Ácido Vanílico/análogos & derivadosRESUMO
Sexually potent and sluggish/impotent male rats were orally treated with an extract of Ferula hermonis (30 and 60 mg/kg). The acute administration stimulated sexual motivation in potent rats and improved copulatory performance in sluggish/impotent rats. This last effect was elicited only by the higher dose, which, in parallel, increased serum testosterone levels in rats. On the contrary, when the extract was subchronically administered (10 days) a marked reduction in the percentage of rats achieving ejaculation was detected, together with a general impairment of the copulatory pattern. Furthermore, the repeated administration of the extract (6 mg/kg/day for 10 days) resulted in a significant reduction of testosterone levels in comparison with controls. The present results discourage a repeated assumption of F. hermonis, while suggesting its acute administration to improve the performance in sexual dysfunctions.
Assuntos
Copulação/efeitos dos fármacos , Disfunção Erétil/tratamento farmacológico , Ferula , Fitoterapia , Preparações de Plantas/farmacologia , Animais , Feminino , Masculino , Ratos , Ratos Sprague-Dawley , Testosterona/sangueRESUMO
This paper reports a RP-HPLC method for the determination in topics of azelaic acid, a keratolytic and anti-comedogenic agent widely used in the treatment of all types of acne. A derivatization step was needed prior to chromatographic analysis because the analyte is lacking in chromophore. A sample clean-up procedure by solid-phase extraction was also developed to analyse azelaic acid in complex matrices, such as pharmaceutical and cosmetic formulations.