[Evaluation of the state of the progeny of mice with damaged kidneys]. / Otsenka sostoianiia potomstva ot myshei s povrezhdennymi pochkami

It was established that increased mortality was characteristic of newborn mice from females with dystrophic lesions of the renal tissue. The kidneys of newborns from these females had a less relative weight as compared with newborns from healthy mice. Other organs of experimental and control newborns did not differ in their relative weight. Hypertrophy of the tubule cells with the signs of picnosis of nuclei was noted in the kidneys of experimental newborn animals. In two-month-old mice of the experimental and control groups the kidneys and other organs (liver, heart, lungs, spleen) had no substantial distinctions in the relative weight. The concentration of urea in the blood of two-month-old mice from females with injured kidneys under protein load was higher than in control two-month-old mice from females treated with 0,85% solution of NaCl which speaks of decreased resistance of kidneys in the animals of experimental group against pathogenic factors.