RESUMO
The drug hypersensitivity syndrome (DHS) is a rare but serious and potentially life-threatening reaction to common drugs in predisposed individuals. The syndrome is a triad of fever, skin eruption, and internal organ involvement. Prompt identification and discontinuation of the offending drug with symptomatic treatment of toxic effects is the mainstay of therapy for DHS.
Assuntos
Antibacterianos/efeitos adversos , Hipersensibilidade a Drogas/diagnóstico , Hipersensibilidade a Drogas/fisiopatologia , Adulto , Educação Médica Continuada , Feminino , Humanos , Ácido Penicilânico/efeitos adversos , Ácido Penicilânico/análogos & derivados , Piperacilina/efeitos adversos , Combinação Piperacilina e TazobactamRESUMO
Giant cell arteritis (GCA) presents clinically as an enlarged, tender, non-pulsatile temporal artery with associated headache and systemic symptoms. We present an unusual case of a patient with an enlarged temporal artery in the absence of other clinical findings. An atypical biopsy result provided the diagnosis and guided treatment.
Assuntos
Dirofilariose/diagnóstico , Dirofilariose/parasitologia , Arterite de Células Gigantes/diagnóstico , Arterite de Células Gigantes/parasitologia , Artérias Temporais/patologia , Idoso , Animais , Biópsia , Dirofilaria/isolamento & purificação , Dirofilariose/patologia , Feminino , Arterite de Células Gigantes/patologia , Humanos , Artérias Temporais/parasitologiaRESUMO
Older adults take almost one-third of the drugs prescribed today yet represent only about 12 percent of the population. Adverse drug events are common in this population, but often these events appear to be preventable. Interest in adverse events related to the use of prescription drugs has rarely been higher or broader. The research community continues to develop new tools to study adverse effects of drugs in individuals and populations. However, the published literature on drug-related adverse events is fraught with problems, starting with the original reports and extending to systematic reviews. Prospective data are missing, adverse drug events are poorly described, and analytical methods are questionable. This leads to problems with imprecise estimates and generalizability of results.
