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1.
Sci Rep ; 11(1): 18324, 2021 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-34526590

RESUMO

Early diagnosis and therapy of liver fibrosis is of utmost importance, especially considering the increased incidence of alcoholic and non-alcoholic liver syndromes. In this work, a systematic study is reported to develop a dual function and biocompatible nanoprobe for liver specific diagnostic and therapeutic applications. A polysaccharide polymer, pullulan stabilized iron oxide nanoparticle (P-SPIONs) enabled high liver specificity via asialogycoprotein receptor mediation. Longitudinal and transverse magnetic relaxation rates of 2.15 and 146.91 mM-1 s-1 respectively and a size of 12 nm, confirmed the T2 weighted magnetic resonance imaging (MRI) efficacy of P-SPIONs. A current of 400A on 5 mg/ml of P-SPIONs raised the temperature above 50 °C, to facilitate effective hyperthermia. Finally, a NIR dye conjugation facilitated targeted dual imaging in liver fibrosis models, in vivo, with favourable histopathological results and recommends its use in early stage diagnosis using MRI and optical imaging, and subsequent therapy using hyperthermia.


Assuntos
Receptor de Asialoglicoproteína/metabolismo , Biomarcadores , Glucanos , Cirrose Hepática/diagnóstico , Cirrose Hepática/metabolismo , Imageamento por Ressonância Magnética/métodos , Nanopartículas de Magnetita , Imagem Óptica/métodos , Animais , Materiais Biocompatíveis , Linhagem Celular Tumoral , Sobrevivência Celular , Fenômenos Químicos , Técnicas de Química Sintética , Compostos Férricos/química , Glucanos/química , Cirrose Hepática/etiologia , Cirrose Hepática/terapia , Nanopartículas de Magnetita/química , Masculino , Sondas Moleculares/síntese química , Sondas Moleculares/química , Terapia de Alvo Molecular/métodos , Ratos , Espécies Reativas de Oxigênio
2.
RSC Adv ; 11(55): 34572-34588, 2021 Oct 25.
Artigo em Inglês | MEDLINE | ID: mdl-35494731

RESUMO

The wide arena of applications opened by nanotechnology is multidimensional. It is already been proven that its prominence can continuously influence human life. The role of stem cells in curing degenerative diseases is another major area of research. Cardiovascular diseases are one of the major causes of death globally. Nanotechnology-assisted stem cell therapy could be used to tackle the challenges faced in the management of cardiovascular diseases. In spite of the positive indications and proven potential of stem cells to differentiate into cardiomyocytes for cardiac repair and regeneration during myocardial infarction, this therapeutic approach still remains in its infancy due to several factors such as non-specificity of injected cells, insignificant survival rate, and low cell retention. Attempts to improve stem cell therapy using nanoparticles have shown some interest among researchers. This review focuses on the major hurdles associated with cardiac stem cell therapy and the role of nanoparticles to overcome the major challenges in this field, including cell modulation, imaging, tracking and gene delivery.

3.
ACS Appl Bio Mater ; 4(7): 5742-5752, 2021 07 19.
Artigo em Inglês | MEDLINE | ID: mdl-35006723

RESUMO

Target-specific reactive oxygen species (ROS)-based cancer treatments with high therapeutic efficacy and minimal side effects have been identified recently as a potentially effective cancer management strategy. Herein, we report the fabrication of a targeted nanotheranostic agent built on an iron oxide nanoparticle-decorated graphene-gold hybrid [plasmonic magnetic nanoprobe (PMNP)] for self-guided magnetic resonance (MR)/surface-enhanced Raman scattering imaging and photothermal therapy (PTT)/chemodynamic therapy (CDT). In the presence of glutathione, which is abundant in the tumor environment, the iron oxide nanoparticles undergo in situ reduction, which in turn generates hydroxyl radicals via a Fenton reaction to realize targeted destruction of tumor cells. Moreover, the localized production of heat benefited from the near-infrared absorption of the PMNP accelerates the intratumoral ROS generation process, with a synergistic effect of CDT/PTT. Furthermore, the probe offers an accurate visualization of the intracellular localization of the material through SERS/MR dual imaging channels. In view of the advantages offered by the tumor-specific stimuli-responsive nature of the probe, the PMNP presents as an effective tool for cancer management.


Assuntos
Antineoplásicos , Neoplasias , Humanos , Imageamento por Ressonância Magnética , Espectroscopia de Ressonância Magnética , Neoplasias/diagnóstico por imagem , Terapia Fototérmica , Espécies Reativas de Oxigênio
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