[Rapid recovery in diploid yeast cells irradiated sequentially with fast electrons and alpha particles]. / Issledovanie bystrogo vosstanovleniia u diploidnykh drozhzhevykh kletok, obluchennykh posledovatel'no bystrymi élektronami i al'fa-chastitsami.

In the present work, fast repair after combined irradiation by fast electrons and alpha particles was studied in diploid yeast cells Saccharomyces cerevisiae of wild-type XS 800 and its radiosensitive mutant XS 1898. It was shown, that the fast repair significantly contribute to detected survival of the wild-type cells, while this repair is absent in XS 1898 mutant cells. An efficiency of the fast repair under combined irradiation (electrons + alpha particles), assessed on DMF of alpha particles, is lower, than that under irradiation by electrons and alpha particles separately.

[The effects of the simultaneous combined irradiation of diploid yeast cells of different genotypes using radiation with different LETs]. / Issledovanie éffektov odnovremennogo kombinirovannogo oblucheniia diploidnykh drozhzhevykh kletok razlichnogo genotipa izlucheniiami s razlichnoi LPE.

Effects of simultaneous irradiation of diploid yeast cells with various genotypes with alpha-particles, gamma-rays or fast electrons were studied. When contribution of sparsely ionizing radiation to the overall dose is small (up to 25%) antagonism was observed, while at the 95% contribution there seems to be a tendency towards synergistic effect; at 50% contribution the results of the simultaneous combined irradiation do not contradict hypothesis on independent effect of radiation with different LET, which also implies a change in the RBE of simultaneous irradiation.

[Fast repair in diploid yeast cells after combined exposure to ionizing radiation with different LET]. / Issledovanie bystrogo vosstanovleniia u diploidnykh drozhzhevykh kletok posle kombinirovannogo vozdeistviia ioniziruiushchikh izluchenii s razlichnymi LPE.

Fast repair in diploid yeast cells Saccharomyces cerevisiae XS800 exposed to the combined irradiation (alpha-particles + high-velocity electrons) was studied. It has been shown that fast repair was significantly more effective after combined irradiation with high doses than after exposure to high-velocity electrons or alpha-particles alone. The regions of radioresistance in the cell survival curves after combined irradiation can be explained by fast post-irradiation repair.

[Formation and study of the dosimetric characteristics of wide fields of fast electrons used to irradiate laboratory animals using the LUE-25 accelerator]. / Formirovanie i issledovanie dozimetricheskikh kharakteristik shirokikh polei bystrykh élektronov dlia oblucheniia laboratornykh zhivotnykh na uskoritele LUE-25.

A mode of formation of wide fields of fast electrons at LUE-25 accelerator is proposed to expose uniformly the extended 4 cm thick biological objects. Dosimetric characteristics of the electron beams have been studied by film and ferrous-sulfate dosimeters. The potencies and limitations of using the dosimeters as a "witness" are discussed.

[Use of the LUE-25 linear electron accelerator for studying the radiobiological effects of high doses of fast electrons]. / Ispol'zovanie LUE-25 dlia issledovaniia radiobiologicheskikh éffektov bol'shikh doz bystrykh élektronov.

In order to study the early biological effects of whole-body and partial exposure of biological objects to high doses of fast electrons a simple and reliable method has been developed for the purposes of the control and correction of the dose-rates. The measurements were made of spatial distribution, in air and water, of the doses used for irradiation of the laboratory animals and cell suspensions with the indicated nonuniformity coefficients.