A Rare Case of Post-parathyroidectomy Calciphylaxis in a Young Patient With End-Stage Renal Disease: A Case Report and Literature Review.

Calciphylaxis is a serious complication in chronic kidney disease (CKD) patients and requires a multidisciplinary approach. Dialysis patients are the most affected, especially those who are obese and diabetic, have liver diseases and autoimmune diseases, or are on systemic glucocorticoids. Parathyroidectomy (PTx) is curative for secondary hyperparathyroidism (SHPT) and calciphylaxis in most cases. Calciphylaxis after parathyroidectomy is a rare presentation. We present a case of a young patient who developed calciphylaxis after parathyroidectomy, an uncommon presentation.

Immunoglobulin G and subclasses placental transfer in fetuses and preterm newborns: a systematic review.

Immunoglobulin G (IgG) and subclasses are the only class of antibodies capable of crossing placenta and providing protection against neonatal infectious diseases, especially in premature infants. This systematic review aimed to review the literature concerning the transplacental transfer of IgG and its subclasses in fetuses and preterm newborns and compare the results with data from term neonates. Eleven studies were included in the final review. Most studies demonstrated a lower transplacental passage of IgG2 than other subclasses in term and preterm newborns and a more efficient passage of total IgG and IgG1 after 37 weeks of gestational age. These results elucidate the physiology of IgG subclass transfer during pregnancy and may explain one of the reasons preterm newborns are especially susceptible to specific pathogens, such as encapsulated bacteria.