RESUMO
Existe un alto número de personas afectadas por infertilidad que requieren de técnicas de reproducción asistida. Por ello, el objetivo de esta revisión ha sido analizar la efectividad de las intervenciones llevadas a cabo en dichas técnicas. Se realizó una revisión sistemática, por pares, en doce bases de datos. Los criterios de inclusión fueron: ensayos clínicos aleatorizados, publicados entre 2011 y 2016, y con una puntuación mayor que dos en la escala Jadad. Las intervenciones farmacológicas efectivas encontradas fueron la administración de hormonas: gonadotropina coriónica humana intrauterina, gonadotrofina y dehidroepiandrosterona, y de metformina. Se localizó una intervención quirúrgica efectiva, raspado endometrial. No se halló ninguna intervención no farmacológica efectiva. Existe una heterogeneidad tanto de intervenciones incluidas en las técnicas de reproducción asistida, como de criterios para medir efectividad (tasa de embarazo, tasa de nacidos vivos o tasa de implantación), siendo necesaria una unificación de criterios
There are a high number of people affected by infertility who require assisted reproduction techniques. For this reason the aim of this review was to analyze the effectiveness of the interventions carried out using these techniques. A systematic peer review was performed on twelve databases. Inclusion criteria were: randomized clinical trials, published between 2011 and 2016, and with a score greater than two on the Jadad scale. The pharmacological interventions that proved effective were the administration of hormones, intrauterine human chorionic gonadotropin, gonadotrophin and dehydroepiandrosterone, and metformin. An effective surgical intervention, endometrial scratching, was identified. No effective non-pharmacological interventions were found. Assisted reproduction techniques show heterogeneity in both the interventions included and effectiveness criteria (pregnancy rate, live birth rate or implantation rate), which makes a unification of criteria necessary
Assuntos
Humanos , Técnicas Reprodutivas/tendências , Saúde Reprodutiva , Resultado do Tratamento , Infertilidade/terapia , Avaliação de Resultado de Intervenções Terapêuticas , Avaliação de Eficácia-Efetividade de Intervenções , Hormônios/administração & dosagem , Gonadotropina Coriônica/administração & dosagem , Metformina/administração & dosagemRESUMO
There are a high number of people affected by infertility who require assisted reproduction techniques. For this reason the aim of this review was to analyze the effectiveness of the interventions carried out using these techniques. A systematic peer review was performed on twelve databases. Inclusion criteria were: randomized clinical trials, published between 2011 and 2016, and with a score greater than two on the Jadad scale. The pharmacological interventions that proved effective were the administration of hormones, intrauterine human chorionic gonadotropin, gonadotrophin and dehydroepiandrosterone, and metformin. An effective surgical intervention, endometrial scratching, was identified. No effective non-pharmacological interventions were found. Assisted reproduction techniques show heterogeneity in both the interventions included and effectiveness criteria (pregnancy rate, live birth rate or implantation rate), which makes a unification of criteria necessary.