RESUMO
OBJECTIVE: To evaluate the effects of hormone therapy (HT) on cognition and subjective quality of life (QoL) in recently postmenopausal women with cognitive complaints. METHODS: Cognitive Complaints in Early Menopause Trial (COGENT) was a randomized, double-blind, placebo-controlled, multicenter, pilot study of 180 healthy postmenopausal women aged 45 to 55 years, randomly assigned to receive either placebo or conjugated equine estrogen 0.625 mg/medroxyprogesterone acetate 2.5 mg for 4 months. Outcome measures included memory, subjective cognition, QoL, sexuality, and sleep, which were assessed at baseline and month 4. RESULTS: The study was terminated before the expected final sample size of 275 due to a decrease in enrollment coinciding with the publication of findings from the Women's Health Initiative. There were no differences between groups on any cognitive or QoL measures, except for an increase in sexual interest and thoughts with HT. Modest negative effects on short- and long-term verbal memory approached significance (p < 0.10). Women with baseline vasomotor symptoms (VMS) showed a decrease in VMS and an improvement in general QoL, but no cognitive benefit vs placebo. CONCLUSIONS: With the power to detect an effect size of >or=0.45, this study suggests potential modest negative effects on verbal memory that are consistent with previous hormone therapy trials in older women.
Assuntos
Transtornos Cognitivos/tratamento farmacológico , Terapia de Reposição de Estrogênios/métodos , Hormônios Esteroides Gonadais/administração & dosagem , Menopausa/fisiologia , Fármacos Neuroprotetores/administração & dosagem , Transtornos Cognitivos/etiologia , Transtornos Cognitivos/fisiopatologia , Método Duplo-Cego , Combinação de Medicamentos , Estrogênios/administração & dosagem , Feminino , Humanos , Acetato de Medroxiprogesterona/administração & dosagem , Memória/efeitos dos fármacos , Memória/fisiologia , Transtornos da Memória/induzido quimicamente , Transtornos da Memória/tratamento farmacológico , Transtornos da Memória/fisiopatologia , Pessoa de Meia-Idade , Testes Neuropsicológicos , Placebos , Falha de TratamentoRESUMO
PIP: Total complement levels were studied in 216 pregnant women, 170 women (aged 18-46 years) taking Non-Ovlon or Ovosiston, and 305 male and female blood donors. Complement titers in the pregnant group were significantly higher than those of controls; those of women using hormonal contraception were similar to those of the pregnant group. The question of steroid induction of immunological phenomena is discussed.^ieng
