[Interaction between Bifidobacterium bifidum, Proteus vulgaris, and Klebsiella pneumoniae 204 in the gastrointestinal tract of gnotobiotic chicks]. / Vzaimodeistvie mezhdu Bifidobacterium bifidum, Proetus vulgaris i Klebsiella pneumoniae 204 v pishchevaritel'nom trakte tsypliat-gnotobiontov.

Experiments on gnotobiont chickens indicated that the strains B. bifidum 1/85 phi, P. vulgaris F-30 and K. pneumoniae 204, when introduced simultaneously into the gastrointestinal tract in a single administration, proliferate there with the pronounced predominance of bifidobacteria. 6 additional administrations of B. bifidum 1/85 phi culture resulted in the complete suppression of microorganisms belonging to the genera Rroteus and Klebsiella as early as 10 days after the introduction of bifidobacteria. These data suggest that it is necessary to use B. bifidum 1/85 phi in cases of intestinal dysbacteriosis characterized by the predominance of microorganisms belonging to the genera Proteus and Klebsiella.

[Antagonistic interrelationships of Bifidobacterium bifidum i Proteus vulgaris in vitro in the digestive tract of gnotobiotic chicks]. / Antagonisticheskie vzaimootnosheniia Bifidobacterium bifidum i Proteus vulgaris in vitro v pishchevaritel'nom trakte tsypliat-gnotobiontov.

The antagonistic relations between Bacterium bifidum, strain I/850 phi, and Proteus vulgaris, strain F-30, were studied. These organisms, when introduced together in equal doses into the digestive tract of gnotobiotic chickens in a single administration, were shown to create certain ecological correlations in various organs with the prevalence of bifidobacteria which exerted no negative influence on Proteus vulgaris. The additional daily administration of bifidobacteria for 3 days running in doses 1000 times as great as the initial dose, the content of both dibifobacteria and Proteus vulgaris in the intestine being at that time at its maximum, resulted in the suppression of the growth of Proteus vulgaris. Our findings indicate that the influence of the pH of the medium should be considered in order to obtain the evidence of significantly pronounced antagonistic relations between the two organisms in vitro.

[Effect of bificol on the intestinal microflora of chronic colitis patients working in antiboitic prodiction]. / Vliianie bifikola na mikrofloru kishechnika bol'nykh knronicheskim kolitom u usloviiakh proizvodstva antibiotikov

Data on the use of bificol, a new Soviet preparation, and its effect on the intestine microflora of patients with chronic colitis occupied in production of penicillin are presented. It was shown that by the 28th day of the preparation use the level of the intestine bacteria in the patients' intestine reliably increased. The number of immobile strains decreased from 67.6 to 36.6 per cent. Bifidoflora normalized by the 14th day of the treatment. Some clinical inprovement, i.e. stool normalization, lessening of the stomach pain, increased appetite were observed by the 4th--5th day of the treatment with bificol. On the basis of the microbiological and clinical data it was shown that treatment of the patients with chronic colitis in antibiotic production should continue for at least 28 days and in individual cases for longer periods of time. It is recommended to use the preparation in 10 doses a day divided into 2 parts.

[Microflora of theintestines of persons in contact with aminoglycosides and penicillin]. / Mikroflora kishechnika liudei, imeiushchikh kontakt s aminoglikozidami i penitsillinom

A total of 90 persons being in contact with aminoglycosides and penicillin were examined. It was found that such a contact resulted in dysbacteriosis of the intestine. The culture of Coli bacteria isolated from the persons had a low fermentative activity and lost their mobility. Bificol, a biological preparation proved to be promising in the treatment of persons with dysfunction of the intestine against the background of dysbacteriosis.

[Microflora of the intestine and biliary tracts in patients with viral hepatitis]. / Mikroflora kishechnika i zhelchevyvodiashchikh putei u bol'nykh virusnym gepatitom

The authors present the results of studying the microflora if the intestine and of the biliary tracts in patients with viral hepatitis; dysbacteriosis was revealed in 53% of the cases. This percentage proved to decrease with clinical recovery. Bile proved to be often contaminated with microbes -- 77% of the samples; this was particularly true in cases with cholestatic variant of the disease and in cases of moderate severity. The fact of prolonged habitation of the microorganisms in the bile system is of importance -- 68% of the patients still had microbial flora in the gall bladder and the biliary tracts by the time of discharge from the hospital.

[Experimental data on hygienic norms for antibiotics of the tetracycline group]. / Eksperimental'nye materialy k gigienicheskomu normirovaniiu antibiotikov tetratsiklinovoi gfuppy

Toxicity of tetracyclines was studied experimentally on different species of laboratory animals. It was shown that tetracycline, oxytetracycline and chlortetracycline were close by their chemical structure and physico-chemical properties, as well as by the main toxicity parameters, i.e. acute toxicity, cumulative activity, skin-irritating and sensitizing effect. Under the conditions of subacute experiments the above 3 antibiotics induced evenly pronounced one direction changes in animals. The data obtained during the experiments provided recommendation of the level of 0.1 mg/m3 as the maximum allowable concentration (MAC) of oxytetracycline and chlortetracycline, i.e. the same level as the previously recommended for tetracycline.