RESUMO
Aspergillosis of the central nervous system (CNS) is a rare, but well described disease in immuno-competent patients. We present a 65-year-old patient who developed neuro-aspergillosis 10 months after severe cranio-facial trauma (Le Fort III). He was treated successfully with surgery including stereotactic drainage and, with Amphotericin B, Liposomal Amphotericin B, and Itraconazol.
Assuntos
Abscesso Encefálico/imunologia , Traumatismos Faciais/cirurgia , Imunocompetência/imunologia , Fraturas Maxilares/cirurgia , Meningite Fúngica/imunologia , Neuroaspergilose/imunologia , Complicações Pós-Operatórias/imunologia , Fraturas Cranianas/cirurgia , Idoso , Anfotericina B/administração & dosagem , Antifúngicos/administração & dosagem , Abscesso Encefálico/diagnóstico , Abscesso Encefálico/tratamento farmacológico , Abscesso Encefálico/cirurgia , Ventrículos Cerebrais/cirurgia , Derivações do Líquido Cefalorraquidiano , Terapia Combinada , Esquema de Medicação , Humanos , Hidrocefalia/cirurgia , Itraconazol/administração & dosagem , Masculino , Meningite Fúngica/diagnóstico , Meningite Fúngica/tratamento farmacológico , Meningite Fúngica/cirurgia , Microcirurgia , Córtex Motor/cirurgia , Neuroaspergilose/diagnóstico , Neuroaspergilose/tratamento farmacológico , Neuroaspergilose/cirurgia , Neuronavegação , Osteotomia de Le Fort , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/tratamento farmacológico , Complicações Pós-Operatórias/cirurgia , Reoperação , Tomografia Computadorizada por Raios XRESUMO
PURPOSE: Urodynamic changes following surgical treatment for lumbar intervertebral disk protrusion were prospectively studied. MATERIALS AND METHODS: We evaluated 98 patients with lumbar intervertebral disk protrusion. Urodynamic evaluation was performed in all patients before and after surgery, and included simultaneous measurement of intravesical and abdominal pressure during bladder filling and voiding, and uroflowmetry (pressure flow measurement). RESULTS: Of the 27 patients with detrusor areflexia preoperatively detrusor activity was normal in only 6 after surgical treatment. Of the 71 patients with normal urodynamic findings preoperatively the findings became abnormal after surgery in 7. CONCLUSIONS: Bladder function frequently remains unchanged after surgery for lumbar intervertebral disk protrusion.
Assuntos
Deslocamento do Disco Intervertebral/cirurgia , Laminectomia , Bexiga Urinária/fisiopatologia , Urodinâmica , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cuidados Pós-Operatórios , Cuidados Pré-Operatórios , Estudos ProspectivosRESUMO
The pharmaceutical availability of nitrofurantoin in three commercial urinary antiseptic preparations for oral use was assessed by an in vitro determination of drug release into a strongly acidic, a weakly acidic and a weakly basic medium. The following parameters are reported: t87.5%, tdiss, X0 (percentage released immediately on contact with medium), krel (relative dissolution rate constant), and dissolution efficiency (DE).
