RESUMO
The mortality of 2,117 workers exposed to trichloroethylene sometime between 1963 and 1976 was studied. Their names were collected from the files of one biochemical laboratory performing urinary trichloroacetic acid determinations and from the Occupational Disease Register of Finland. Both the total mortality (SMR 69) and the cancer mortality (SMR 77) were lower than expected. Because of the young age structure and the brief follow-up time the results should be interpreted with caution. They suggest, however, that given as short a latency period as 6 to 13 years, trichloroethylene is not a strong human carcinogen. The present material provides a cohort with defined exposure for further follow-up.
Assuntos
Tricloroetileno/intoxicação , Adolescente , Adulto , Idoso , Exposição Ambiental , Métodos Epidemiológicos , Feminino , Finlândia , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade , Neoplasias/mortalidade , Ácido Tricloroacético/urinaRESUMO
Smoking habits and random measurements of the proportion of haemoglobin bound to carbon monoxide (COHb%) were examined for their association with atherosclerotic diseases in 1068 men aged 55 to 74 years from rural areas of Finland. COHb% and smoking history were similarly associated with claudication and coronary heart disease. Random measurements of COHb% did not show a better overall relation to the prevalence of atherosclerotic diseases than smoking history, though COHb% showed a stronger association with a probable previous myocardial infarction. Further studies are needed to clarify the role of carbon monoxide in atherosclerosis.
