RESUMO
Tumors of the small bowel, both benign and malignant, are relatively uncommon and often present a diagnostic challenge as their symptoms are often vague. This review article outlines the incidence, presentation, diagnosis, and management of small bowel tumors.
Assuntos
Neoplasias Duodenais , Intestino Delgado/patologia , Neoplasias do Jejuno , Adenocarcinoma/epidemiologia , Adenocarcinoma/patologia , Adenoma/diagnóstico , Glândulas Duodenais/patologia , Tumor Carcinoide/diagnóstico , Neoplasias Duodenais/diagnóstico , Neoplasias Duodenais/epidemiologia , Neoplasias Duodenais/patologia , Síndrome do Hamartoma Múltiplo/diagnóstico , Humanos , Incidência , Neoplasias do Jejuno/diagnóstico , Neoplasias do Jejuno/epidemiologia , Neoplasias do Jejuno/patologia , Leiomioma/diagnóstico , Leiomiossarcoma/diagnóstico , Lipoma/diagnóstico , Linfoma/diagnóstico , Linfoma/patologia , Síndrome de Peutz-Jeghers/diagnósticoRESUMO
Poorly differentiated adenocarcinoma with lymphoid stroma occurred in the transverse colon of a 77 year old female. Numerous small lymphocytes and plasma cells were distributed in the tumor stroma. Non-isotopic in situ hybridization study for Epstein-Barr (EBV)-related small nuclear RNA (EBER-1) revealed positive signals in the nuclei of a few lymphocytes in the tumor stroma, while the tumor cell nuclei were not labeled. Immunostaining for latent membrane protein-1 was negative. The significance of detection of the EBV-infected lymphocytes in the colon tumor stroma is discussed.
Assuntos
Adenocarcinoma/virologia , Neoplasias do Colo/virologia , Infecções por Herpesviridae/patologia , Herpesvirus Humano 4/genética , Herpesvirus Humano 4/isolamento & purificação , Linfócitos/virologia , Adenocarcinoma/complicações , Adenocarcinoma/patologia , Idoso , Neoplasias do Colo/complicações , Neoplasias do Colo/patologia , Feminino , Genoma Viral , Infecções por Herpesviridae/complicações , Humanos , Técnicas Imunoenzimáticas , Hibridização In SituRESUMO
Poorly differentiated small cell neuroendocrine (NE) carcinoma of the colon and rectum is a rare primary epithelial malignancy at this location. A case of a highly aggressive NE tumor of small cell type, combined with non-invasive well-differentiated papillary adenocarcinoma in villous adenoma is reported. The patient died rapidly with massive and progressive liver metastasis. The tumor cells were argyrophilic and diffusely immunoreactive for neuronspecific enolase and synaptophysin. Ultrastructural analysis disclosed NE-type cored granules in most of the small tumor cells. NE tumors of the colon and rectum are briefly reviewed.
Assuntos
Carcinoma Neuroendócrino/patologia , Carcinoma de Células Pequenas/patologia , Neoplasias Retais/patologia , Adenocarcinoma Papilar/patologia , Adenoma Viloso/patologia , Carcinoma Neuroendócrino/ultraestrutura , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Primárias Múltiplas/patologiaRESUMO
Leiomyosarcoma of the extremities is an unusual tumor. Herein we report a unique and what we believe is the first case of a patient in whom there was complete disappearance of such a tumor following regional hyperthermia and chemotherapy.
