Outcome of early emergency intubation and early emergency dialysis in deliberate self-harm with formic acid in a tertiary care center in South India: A retrospective cohort study.

OBJECTIVE: The objective is to evaluate the outcome of early emergency intubation and early dialysis in formic acid (FA) poisoning and to determine the clinical features associated with its mortality. METHODS: It is a retrospective cohort study of 78 patients who presented to the emergency medicine department from July 2008 to June 2015 with alleged history and clinical features of FA poisoning. The outcome of early intubation and early dialysis was studied in terms of 7-day and 30-day mortality. The outcome was compared in severe and not severe groups separately. Severity was graded according to Med-Tu chart used for corrosive poisoning. RESULTS: In the severe group (n = 53), early dialysis was done in 15 patients. There was 53% (n = 8) 30-day mortality. In the group where early dialysis was not done there was a significant increase in mortality 92.1% (n = 35). This was statistically significant with a P = 0.003. In a similar fashion 7-day mortality was analyzed in the severe group where mortality was higher when early dialysis was not done. In not severe group early dialysis has minimally decreased the mortality. Early intubation in severe group did not demonstrate any mortality benefit. Patients who were intubated early and not intubated early had equally high mortality. In not severe group, intubation could not make any significant difference in mortality. CONCLUSION: In this retrospective study, we observed that early dialysis in the severe group has a better outcome in terms of 7-day and 30-day mortality.

Synergistic treatment strategies to combat resistant bacterial infections using Schiff base modified nanoparticulate - hydrogel system.

Antibiotic resistance is of much prevalence and is one of the alarming realities for the rise in morbidity and mortality. Antibiotics; once regarded as wonder drugs have lost its credit of combating bacteria due to the rapid rise in variety of nosocomial pathogens. The underlying cause for the resistance spread is due to sudden drift in genetic mutation and the recalcitrant behavior of bacterial species. On the other hand, illegal and overconsumption of drugs fuels up the issue, wherein resistance development is directly proportional to the rate of drug consumption. Our pursuit was in reviving antibiotic, and further repurposing them into more potent formulation with reduced side effects to completely deplete resistant bacteria. In this work we present gentamicin encapsulated zein nanoparticle modified with Schiff base incorporated in immobilized chitosan-polyvinyl alcohol gel matrix([GM-ZNP]PG CsPVA) resulting in synergistic antibacterial activity. Schiff base modified zein nanoparticle exhibited an average diameter of 240 ±â€¯8 nm and stability of -29.85 ±â€¯2 mV. The nanocomposite system exhibited enhanced penetration rate when applied to dermis eliciting combinatorial antibacterial activity. Gentamicin in combination with Schiff base was found to lyse bacteria by ruining its cell integrity as depicted by SEM analysis. The formulation upon application stays intact to the impaired dermal tissues and releases drug in a sustained manner without the need of recurrent administration. The gel system was extremely biocompatible towards L929 cells without any toxicity. Overall, the work reports use of [GM-ZNP]PG CsPVA for resistant bacterial infections.