Brain Tumor Class Detection in Flair/T2 Modality MRI Slices Using Elephant-Herd Algorithm Optimized Features.

Several advances in computing facilities were made due to the advancement of science and technology, including the implementation of automation in multi-specialty hospitals. This research aims to develop an efficient deep-learning-based brain-tumor (BT) detection scheme to detect the tumor in FLAIR- and T2-modality magnetic-resonance-imaging (MRI) slices. MRI slices of the axial-plane brain are used to test and verify the scheme. The reliability of the developed scheme is also verified through clinically collected MRI slices. In the proposed scheme, the following stages are involved: (i) pre-processing the raw MRI image, (ii) deep-feature extraction using pretrained schemes, (iii) watershed-algorithm-based BT segmentation and mining the shape features, (iv) feature optimization using the elephant-herding algorithm (EHA), and (v) binary classification and verification using three-fold cross-validation. Using (a) individual features, (b) dual deep features, and (c) integrated features, the BT-classification task is accomplished in this study. Each experiment is conducted separately on the chosen BRATS and TCIA benchmark MRI slices. This research indicates that the integrated feature-based scheme helps to achieve a classification accuracy of 99.6667% when a support-vector-machine (SVM) classifier is considered. Further, the performance of this scheme is verified using noise-attacked MRI slices, and better classification results are achieved.

Deep belief network-based approach for detecting Alzheimer's disease using the multi-omics data.

Alzheimer's disease (AD) is the most uncertain form of Dementia in terms of finding out the mechanism. AD does not have a vital genetic factor to relate to. There were no reliable techniques and methods to identify the genetic risk factors associated with AD in the past. Most of the data available were from the brain images. However, recently, there have been drastic advancements in the high-throughput techniques in bioinformatics. It has led to focused researches in discovering the AD causing genetic risk factors. Recent analysis has resulted in considerable prefrontal cortex data with which classification and prediction models can be developed for AD. We have developed a Deep Belief Network-based prediction model using the DNA Methylation and Gene Expression Microarray Data, with High Dimension Low Sample Size (HDLSS) issues. To overcome the HDLSS challenge, we performed a two-layer feature selection considering the biological aspects of the features as well. In the two-layered feature selection approach, first the differentially expressed genes and differentially methylated positions are identified, then both the datasets are combined using Jaccard similarity measure. As the second step, an ensemble-based feature selection approach is implemented to further narrow down the gene selection. The results show that the proposed feature selection technique outperforms the existing commonly used feature selection techniques, such as Support Vector Machine Recursive Feature Elimination (SVM-RFE), and Correlation-based Feature Selection (CBS). Furthermore, the Deep Belief Network-based prediction model performs better than the widely used Machine Learning models. Also, the multi-omics dataset shows promising results compared to the single omics.

A framework to distinguish healthy/cancer renal CT images using the fused deep features.

Introduction: Cancer happening rates in humankind are gradually rising due to a variety of reasons, and sensible detection and management are essential to decrease the disease rates. The kidney is one of the vital organs in human physiology, and cancer in the kidney is a medical emergency and needs accurate diagnosis and well-organized management. Methods: The proposed work aims to develop a framework to classify renal computed tomography (CT) images into healthy/cancer classes using pre-trained deep-learning schemes. To improve the detection accuracy, this work suggests a threshold filter-based pre-processing scheme, which helps in removing the artefact in the CT slices to achieve better detection. The various stages of this scheme involve: (i) Image collection, resizing, and artefact removal, (ii) Deep features extraction, (iii) Feature reduction and fusion, and (iv) Binary classification using five-fold cross-validation. Results and discussion: This experimental investigation is executed separately for: (i) CT slices with the artefact and (ii) CT slices without the artefact. As a result of the experimental outcome of this study, the K-Nearest Neighbor (KNN) classifier is able to achieve 100% detection accuracy by using the pre-processed CT slices. Therefore, this scheme can be considered for the purpose of examining clinical grade renal CT images, as it is clinically significant.

MRI brain tumor segmentation using residual Spatial Pyramid Pooling-powered 3D U-Net.

Brain tumor diagnosis has been a lengthy process, and automation of a process such as brain tumor segmentation speeds up the timeline. U-Nets have been a commonly used solution for semantic segmentation, and it uses a downsampling-upsampling approach to segment tumors. U-Nets rely on residual connections to pass information during upsampling; however, an upsampling block only receives information from one downsampling block. This restricts the context and scope of an upsampling block. In this paper, we propose SPP-U-Net where the residual connections are replaced with a combination of Spatial Pyramid Pooling (SPP) and Attention blocks. Here, SPP provides information from various downsampling blocks, which will increase the scope of reconstruction while attention provides the necessary context by incorporating local characteristics with their corresponding global dependencies. Existing literature uses heavy approaches such as the usage of nested and dense skip connections and transformers. These approaches increase the training parameters within the model which therefore increase the training time and complexity of the model. The proposed approach on the other hand attains comparable results to existing literature without changing the number of trainable parameters over larger dimensions such as 160 × 192 × 192. All in all, the proposed model scores an average dice score of 0.883 and a Hausdorff distance of 7.84 on Brats 2021 cross validation.

Advancing genome editing with artificial intelligence: opportunities, challenges, and future directions.

Clustered regularly interspaced short palindromic repeat (CRISPR)-based genome editing (GED) technologies have unlocked exciting possibilities for understanding genes and improving medical treatments. On the other hand, Artificial intelligence (AI) helps genome editing achieve more precision, efficiency, and affordability in tackling various diseases, like Sickle cell anemia or Thalassemia. AI models have been in use for designing guide RNAs (gRNAs) for CRISPR-Cas systems. Tools like DeepCRISPR, CRISTA, and DeepHF have the capability to predict optimal guide RNAs (gRNAs) for a specified target sequence. These predictions take into account multiple factors, including genomic context, Cas protein type, desired mutation type, on-target/off-target scores, potential off-target sites, and the potential impacts of genome editing on gene function and cell phenotype. These models aid in optimizing different genome editing technologies, such as base, prime, and epigenome editing, which are advanced techniques to introduce precise and programmable changes to DNA sequences without relying on the homology-directed repair pathway or donor DNA templates. Furthermore, AI, in collaboration with genome editing and precision medicine, enables personalized treatments based on genetic profiles. AI analyzes patients' genomic data to identify mutations, variations, and biomarkers associated with different diseases like Cancer, Diabetes, Alzheimer's, etc. However, several challenges persist, including high costs, off-target editing, suitable delivery methods for CRISPR cargoes, improving editing efficiency, and ensuring safety in clinical applications. This review explores AI's contribution to improving CRISPR-based genome editing technologies and addresses existing challenges. It also discusses potential areas for future research in AI-driven CRISPR-based genome editing technologies. The integration of AI and genome editing opens up new possibilities for genetics, biomedicine, and healthcare, with significant implications for human health.

A Multistage Heterogeneous Stacking Ensemble Model for Augmented Infant Cry Classification.

Understanding the reason for an infant's cry is the most difficult thing for parents. There might be various reasons behind the baby's cry. It may be due to hunger, pain, sleep, or diaper-related problems. The key concept behind identifying the reason behind the infant's cry is mainly based on the varying patterns of the crying audio. The audio file comprises many features, which are highly important in classifying the results. It is important to convert the audio signals into the required spectrograms. In this article, we are trying to find efficient solutions to the problem of predicting the reason behind an infant's cry. In this article, we have used the Mel-frequency cepstral coefficients algorithm to generate the spectrograms and analyzed the varying feature vectors. We then came up with two approaches to obtain the experimental results. In the first approach, we used the Convolution Neural network (CNN) variants like VGG16 and YOLOv4 to classify the infant cry signals. In the second approach, a multistage heterogeneous stacking ensemble model was used for infant cry classification. Its major advantage was the inclusion of various advanced boosting algorithms at various levels. The proposed multistage heterogeneous stacking ensemble model had the edge over the other neural network models, especially in terms of overall performance and computing power. Finally, after many comparisons, the proposed model revealed the virtuoso performance and a mean classification accuracy of up to 93.7%.

Improving the Classification of Alzheimer's Disease Using Hybrid Gene Selection Pipeline and Deep Learning.

Alzheimer's is a progressive, irreversible, neurodegenerative brain disease. Even with prominent symptoms, it takes years to notice, decode, and reveal Alzheimer's. However, advancements in technologies, such as imaging techniques, help in early diagnosis. Still, sometimes the results are inaccurate, which delays the treatment. Thus, the research in recent times focused on identifying the molecular biomarkers that differentiate the genotype and phenotype characteristics. However, the gene expression dataset's generated features are huge, 1,000 or even more than 10,000. To overcome such a curse of dimensionality, feature selection techniques are introduced. We designed a gene selection pipeline combining a filter, wrapper, and unsupervised method to select the relevant genes. We combined the minimum Redundancy and maximum Relevance (mRmR), Wrapper-based Particle Swarm Optimization (WPSO), and Auto encoder to select the relevant features. We used the GSE5281 Alzheimer's dataset from the Gene Expression Omnibus We implemented an Improved Deep Belief Network (IDBN) with simple stopping criteria after choosing the relevant genes. We used a Bayesian Optimization technique to tune the hyperparameters in the Improved Deep Belief Network. The tabulated results show that the proposed pipeline shows promising results.

Low-Light Image Enhancement Based on Generative Adversarial Network.

Image enhancement is considered to be one of the complex tasks in image processing. When the images are captured under dim light, the quality of the images degrades due to low visibility degenerating the vision-based algorithms' performance that is built for very good quality images with better visibility. After the emergence of a deep neural network number of methods has been put forward to improve images captured under low light. But, the results shown by existing low-light enhancement methods are not satisfactory because of the lack of effective network structures. A low-light image enhancement technique (LIMET) with a fine-tuned conditional generative adversarial network is presented in this paper. The proposed approach employs two discriminators to acquire a semantic meaning that imposes the obtained results to be realistic and natural. Finally, the proposed approach is evaluated with benchmark datasets. The experimental results highlight that the presented approach attains state-of-the-performance when compared to existing methods. The models' performance is assessed using Visual Information Fidelitysse, which assesses the generated image's quality over the degraded input. VIF obtained for different datasets using the proposed approach are 0.709123 for LIME dataset, 0.849982 for DICM dataset, 0.619342 for MEF dataset.

ResMem-Net: memory based deep CNN for image memorability estimation.

Image memorability is a very hard problem in image processing due to its subjective nature. But due to the introduction of Deep Learning and the large availability of data and GPUs, great strides have been made in predicting the memorability of an image. In this paper, we propose a novel deep learning architecture called ResMem-Net that is a hybrid of LSTM and CNN that uses information from the hidden layers of the CNN to compute the memorability score of an image. The intermediate layers are important for predicting the output because they contain information about the intrinsic properties of the image. The proposed architecture automatically learns visual emotions and saliency, shown by the heatmaps generated using the GradRAM technique. We have also used the heatmaps and results to analyze and answer one of the most important questions in image memorability: "What makes an image memorable?". The model is trained and evaluated using the publicly available Large-scale Image Memorability dataset (LaMem) from MIT. The results show that the model achieves a rank correlation of 0.679 and a mean squared error of 0.011, which is better than the current state-of-the-art models and is close to human consistency (p = 0.68). The proposed architecture also has a significantly low number of parameters compared to the state-of-the-art architecture, making it memory efficient and suitable for production.

Evaluating Deep Neural Network Architectures with Transfer Learning for Pneumonitis Diagnosis.

Pneumonitis is an infectious disease that causes the inflammation of the air sac. It can be life-threatening to the very young and elderly. Detection of pneumonitis from X-ray images is a significant challenge. Early detection and assistance with diagnosis can be crucial. Recent developments in the field of deep learning have significantly improved their performance in medical image analysis. The superior predictive performance of the deep learning methods makes them ideal for pneumonitis classification from chest X-ray images. However, training deep learning models can be cumbersome and resource-intensive. Reusing knowledge representations of public models trained on large-scale datasets through transfer learning can help alleviate these challenges. In this paper, we compare various image classification models based on transfer learning with well-known deep learning architectures. The Kaggle chest X-ray dataset was used to evaluate and compare our models. We apply basic data augmentation and fine-tune our feed-forward classification head on the models pretrained on the ImageNet dataset. We observed that the DenseNet201 model outperforms other models with an AUROC score of 0.966 and a recall score of 0.99. We also visualize the class activation maps from the DenseNet201 model to interpret the patterns recognized by the model for prediction.

Identity preserving multi-pose facial expression recognition using fine tuned VGG on the latent space vector of generative adversarial network.

Facial expression is the crucial component for human beings to express their mental state and it has become one of the prominent areas of research in computer vision. However, the task becomes challenging when the given facial image is non-frontal. The influence of poses on facial images is alleviated using an encoder of a generative adversarial network capable of learning pose invariant representations. State-of-art results for image generation are achieved using styleGAN architecture. An efficient model is proposed to embed the given image into the latent vector space of styleGAN. The encoder extracts high-level features of the facial image and encodes them into the latent space. Rigorous analysis of semantics hidden in the latent space of styleGAN is performed. Based on the analysis, the facial image is synthesized, and facial expressions are recognized using an expression recognition neural network. The original image is recovered from the features encoded in the latent space. Semantic editing operations like face rotation, style transfer, face aging, image morphing and expression transfer can be performed on the image obtained from the image generated using the features encoded latent space of styleGAN. L2 feature-wise loss is applied to warrant the quality of the rebuilt image. The facial image is then fed into the attribute classifier to extract high-level features, and the features are concatenated to perform facial expression classification. Evaluations are performed on the generated results to demonstrate that state-of-art results are achieved using the proposed method.

Deep Learning Assisted Neonatal Cry Classification via Support Vector Machine Models.

Neonatal infants communicate with us through cries. The infant cry signals have distinct patterns depending on the purpose of the cries. Preprocessing, feature extraction, and feature selection need expert attention and take much effort in audio signals in recent days. In deep learning techniques, it automatically extracts and selects the most important features. For this, it requires an enormous amount of data for effective classification. This work mainly discriminates the neonatal cries into pain, hunger, and sleepiness. The neonatal cry auditory signals are transformed into a spectrogram image by utilizing the short-time Fourier transform (STFT) technique. The deep convolutional neural network (DCNN) technique takes the spectrogram images for input. The features are obtained from the convolutional neural network and are passed to the support vector machine (SVM) classifier. Machine learning technique classifies neonatal cries. This work combines the advantages of machine learning and deep learning techniques to get the best results even with a moderate number of data samples. The experimental result shows that CNN-based feature extraction and SVM classifier provides promising results. While comparing the SVM-based kernel techniques, namely radial basis function (RBF), linear and polynomial, it is found that SVM-RBF provides the highest accuracy of kernel-based infant cry classification system provides 88.89% accuracy.

Performance Assessment of Certain Machine Learning Models for Predicting the Major Depressive Disorder among IT Professionals during Pandemic times.

Major depressive disorder (MDD) is the most common mental disorder in the present day as all individuals' lives, irrespective of being employed or unemployed, is going through the depression phase at least once in their lifetime. In simple terms, it is a mood disturbance that can persist for an individual for more than a few weeks to months. In MDD, in most cases, the individuals do not consult a professional, and even if being consulted, the results are not significant as the individuals find it challenging to identify whether they are depressed or not. Depression, most of the time, cooccurs with anxiety and leads to suicide in few cases, among the employees, who are about to handle the pressure at work and home and mostly unnoticing such problems. This is why this work aims to analyze the IT employees who are mostly working with targets. The artificial neural network, which is modeled loosely like the brain, has proved in recent days that it can perform better than most of the classification algorithms. This study has implemented the multilayered neural perceptron and experimented with the backpropagation technique over the data samples collected from IT professionals. This study aims to develop a model that can classify depressed individuals from those who are not depressed effectively with the data collected from them manually and through sensors. The results show that deep-MLP with backpropagation outperforms other machine learning-based models for effective classification.

A Hybrid Framework for Intrusion Detection in Healthcare Systems Using Deep Learning.

The unbounded increase in network traffic and user data has made it difficult for network intrusion detection systems to be abreast and perform well. Intrusion Systems are crucial in e-healthcare since the patients' medical records should be kept highly secure, confidential, and accurate. Any change in the actual patient data can lead to errors in the diagnosis and treatment. Most of the existing artificial intelligence-based systems are trained on outdated intrusion detection repositories, which can produce more false positives and require retraining the algorithm from scratch to support new attacks. These processes also make it challenging to secure patient records in medical systems as the intrusion detection mechanisms can become frequently obsolete. This paper proposes a hybrid framework using Deep Learning named "ImmuneNet" to recognize the latest intrusion attacks and defend healthcare data. The proposed framework uses multiple feature engineering processes, oversampling methods to improve class balance, and hyper-parameter optimization techniques to achieve high accuracy and performance. The architecture contains <1 million parameters, making it lightweight, fast, and IoT-friendly, suitable for deploying the IDS on medical devices and healthcare systems. The performance of ImmuneNet was benchmarked against several other machine learning algorithms on the Canadian Institute for Cybersecurity's Intrusion Detection System 2017, 2018, and Bell DNS 2021 datasets which contain extensive real-time and latest cyber attack data. Out of all the experiments, ImmuneNet performed the best on the CIC Bell DNS 2021 dataset with about 99.19% accuracy, 99.22% precision, 99.19% recall, and 99.2% ROC-AUC scores, which are comparatively better and up-to-date than other existing approaches in classifying between requests that are normal, intrusion, and other cyber attacks.

Recent Advances in Evolving Computing Paradigms: Cloud, Edge, and Fog Technologies.

Cloud computing has become integral lately due to the ever-expanding Internet-of-things (IoT) network. It still is and continues to be the best practice for implementing complex computational applications, emphasizing the massive processing of data. However, the cloud falls short due to the critical constraints of novel IoT applications generating vast data, which entails a swift response time with improved privacy. The newest drift is moving computational and storage resources to the edge of the network, involving a decentralized distributed architecture. The data processing and analytics perform at proximity to end-users, and overcome the bottleneck of cloud computing. The trend of deploying machine learning (ML) at the network edge to enhance computing applications and services has gained momentum lately, specifically to reduce latency and energy consumed while optimizing the security and management of resources. There is a need for rigorous research efforts oriented towards developing and implementing machine learning algorithms that deliver the best results in terms of speed, accuracy, storage, and security, with low power consumption. This extensive survey presented on the prominent computing paradigms in practice highlights the latest innovations resulting from the fusion between ML and the evolving computing paradigms and discusses the underlying open research challenges and future prospects.