Immune reactions associated with silicone-based ventriculo-peritoneal shunt malfunctions in children.

The implantation of ventriculo-peritoneal (VP) shunting systems is the most commonly performed neurological procedure in children with hydrocephalus. Although the overall complication risk is low, the cumulative risk of shunt failure is high and unfortunately results in a high prevalence of revision surgeries. In this study, we explored the concept that some pediatric patients may develop an immune response to either the proteins attached to the silicone implant surface or to the biomaterial itself, and that this reaction may contribute to VP shunt failure in some individuals. The data displays that the sterile shunt malfunction group had a higher rate of protein deposition and increased levels of autoantibodies to the extracted surface proteins as compared to individuals with functioning shunting systems. The precise nature of the shunt-bound proteins that serve as antigens in this experiment have not yet been determined. The data also indicated that some individuals develop antibodies to polymeric substances that cross-react with partially polymerized acrylamide. The detection of significant amounts of shunt-bound protein, antibody responses to these proteins and to polymeric substances suggest that an immunological response to these proteins may play a role in the mechanism behind sterile shunt malfunctions.

Impact of an asthma program on the quality of life of children in an urban setting.

A comprehensive asthma program involving a pharmacist and physician evaluated quality of life (QOL) for children with asthma and the relationship between changes in QOL and traditional outcomes. The program consisted of aggressive medical management and a comprehensive education program. Children were from an inner-city population who had been referred to a specialist. Twenty of the 29 children enrolled in the program were available for 1-year follow-up. Significant improvements were seen in overall QOL scores and in each domain in the instrument, which exceeded the minimal important difference. A strong relationship was not found between changes in QOL total score and changes in asthma questionnaire score, frequency of nocturnal asthma, symptomatic days, and exercise tolerance. Further research is necessary to support these findings.

Upper airway disorders and asthma: a syndrome of airway inflammation.

OBJECTIVE: This article presents recent evidence of an upper and lower airway link. After reading this article, readers should have an understanding of the evidence for the pathologic relationship between asthma and upper airway disorders such as rhinosinusitis and allergic rhinitis. DATA SOURCES: Epidemiologic, pathophysiologic, and treatment outcomes studies were used. Only literature in the English language was reviewed. STUDY SELECTION: Material was taken from academic/scholarly journals. RESULTS: Epidemiologic data indicate that asthma and allergic rhinitis frequently coexist, with rhinitis symptoms reported among 19 to 94% of asthma patients, and asthma reported among 19 to 38% of those with allergic rhinitis. Allergic rhinitis often precedes asthma symptomatology and has been shown to be a risk factor for the development of asthma. The severity of one's allergic rhinitis also has been shown to be directly correlated with asthma severity. Patients with allergic rhinitis exhibit increased eosinophil activity in both upper and lower airways. In these patients, nasal allergen challenge can induce increased bronchial hyperresponsiveness, suggesting that upper and lower airway disorders share common inflammatory features. Treatment of rhinitis symptoms has been shown to produce better asthma symptom control and, in a few studies, the improvement of airway function in patients with concomitant asthma. CONCLUSIONS: Evidence suggests that upper respiratory disorders such as allergic rhinitis and rhinosinusitis are different facets of a larger systemic inflammatory syndrome involving both the upper and lower airways. Several important questions remain to be answered before the nature of the relationship between lower and upper airway disorders is fully understood.