[Comparison of albumin analysis by fluorescent method with other clinical laboratory parameters in purulent peritonitis]. / Sravnitel'nyi analiz al'bumina, issledovannogo fliuorestsentnym metodom, i drugikh kliniko-laboratornykh pokazatelei pri gnoinom peritonite.

The concentration and properties of the blood-albumin linkage centers were examined by the method fluorescent probes, besides, the general clinical-and-laboratory indices in the blood serum of patients with diffusive purulent peritonitis were determined. The parameters as obtained by the method of fluorescent probes revealed a valuable information on a patients' severity condition and on a forecasted disease evolution; finally, they surpass, in a majority of cases, the generally accepted clinical-and-laboratory tests applicable to similar conditions.

[Fluorescent method of studying the binding sites of serum albumin for assessing status of patients with purulent-septic diseases]. / Fliuorestsentnyi metod issledovaniia sviazyvaiushchikh tsentrov syvorotochnogo al'bumina dlia otsenki sostoianiia bol'nykh gnoino-septicheskimi zabolevaniiami.

The concentration and properties of the binding centers of the albumin molecule in blood serum of patients with pyo-septic diseases (peritonitis, pancreatonecrosis and sepsis) were investigated. The patients of this category were shown to have a considerably decreased and greatly variable indices of the general concentration of albumin and of effective concentration of albumin in their blood serum. The fluorescent indices were established to correlate with the severity of the disease, efficiency of treatment, prognosis of the development of the disease and its outcome.

[Sepsis on the threshold of the 21st century: the basic results. New problems and the immediate tasks]. / Sepsis na poroge XXI veka: osnovnye itogi. Novye problemy i blizhaishie zadachi.

The authors validate their positions in terminology of sepsis and evaluation of its severity, based on analysis of this problem evolution during the century, review of the most significant publications, and their own findings. Problems of intensive care are discussed. The authors claim that intensive care methods should be determined by the phase of the systemic inflammatory response syndrome (SIRS). One of the nearest goals for scientists and public health managers is an interdisciplinary consensus on terminology of sepsis and diagnostic criteria, creation of a standard protocol of laboratory studies and treatment, search for available markers of SIRS of infectious origin, regulation of cytokine response, creation of local data bases reflecting the etiological structure of the agents and their antibiotic resistance.