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Acta Pharm ; 74(2): 301-313, 2024 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-38815204

RESUMO

The principal function of skin is to form an effective barrier between the human body and its environment. Impaired barrier function represents a precondition for the development of skin diseases such as atopic dermatitis (AD), which is the most common inflammatory skin disease characterized by skin barrier dysfunction. AD significantly affects patients' quality of life, thus, there is a growing interest in the development of novel delivery systems that would improve therapeutic outcomes. Herein, eight novel lyotropic liquid crystals (LCCs) were investigated for the first time in a double-blind, interventional, before-after, single-group trial with healthy adult subjects and a twice-daily application regimen. LCCs consisted of constituents with skin regenerative properties and exhibited lamellar micro-structure, especially suitable for dermal application. The short- and long-term effects of LCCs on TEWL, SC hydration, erythema index, melanin index, and tolerability were determined and compared with baseline. LCCs with the highest oil content and lecithin/Tween 80 mixture stood out by providing a remarkable 2-fold reduction in TEWL values and showing the most distinctive decrease in skin erythema levels in both the short- and long-term exposure. Therefore, they exhibit great potential for clinical use as novel delivery systems for AD treatment, capable of repairing skin barrier function.


Assuntos
Administração Cutânea , Dermatite Atópica , Óleo de Semente do Linho , Cristais Líquidos , Pele , Humanos , Cristais Líquidos/química , Método Duplo-Cego , Adulto , Masculino , Feminino , Pele/efeitos dos fármacos , Pele/metabolismo , Dermatite Atópica/tratamento farmacológico , Óleo de Semente do Linho/química , Óleo de Semente do Linho/farmacologia , Adulto Jovem , Eritema/tratamento farmacológico , Cannabis/química , Pessoa de Meia-Idade , Sistemas de Liberação de Medicamentos/métodos , Extratos Vegetais
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