1.
Farmaco
; 59(3): 175-83, 2004 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14987980
RESUMO
Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester, a potent and selective mGluR1 non-competitive antagonist, we report here a detailed exploration of the C-2 position of this scaffold with the preparation of differently substituted amides. Great improvement of the pharmacokinetic properties has been achieved through this exercise.