[Effect of radioactive iodine therapy and surgical treatment of thyrotoxicosis on the blood level of thyrotropin]. / Vliianie terapii radioaktivnym iodom i khirurgicheskogo lecheniia tireotoksikoza na uroven tireotropnogo gormona gipofiza v krovi.

The radioimmunological method was applied to the study of the thyrotropic hormone (TTH) content in the blood of 308 patients with thyrotoxicosis at various stages of therapy with radioactive iodine and surgical treatment. After 131I treatment and elimination of the thyrotoxicosis symptoms TTH rose 1 to 2 years and 5 to 10 years after the onset of remission, this being regarded as an adaptive response to the changing thyroid activity. The hypothalamo-hypophysio-thyroid interaction was restored after the successful 131I therapy. However, surgical treatment of thyrothoxicosis did not lead to restoration of such interaction for 5 years--no changes of the TTH level followed either the "primary" subtotal thyroidectomy or repeated operation for the relapsing form of the disease.

[State of hypophyseal thyrotropic function in the complex treatment of thyroid cancer]. / Sostoianie tireotropnoi funktsii gipofiza pri kompleksnom lechenii raka shchitovidnoi zhelezy.

Radioimmune assay of the hypophyseal thyreotropic hormone (THH) in blood of 89 patients with thyroid cancer in stage II and III indicated that the THH level prior to the treatment did not differ from that in healthy individuals--3,0 +/- 0,6 ng/ml. Subtotal thyroidectomy was associated with a sharp riste of the thyreotropin concentration in blood during the immediately 7--20 days after surgery followed by its normalization in 1--2 months. Immediately after distant gamma-therapy the THH concentration did not differ from the initial value, but in later terms it was dependent on the clinical patient's state i.e. under hypothyreosis it was increased. Increased THH level was also noted in development of the cancer recurrence following the applied therapy (without hypothyreosis).