RESUMO
33 patients with complaints of hyposalivation (21 in a 33 with syaloadenopatya and 12 in a 33 with syalosis out of the acute stage of disease) were examined. Complex examination of the saliva glands, analysis of the haemokynes in the various mediums of organism and thyoles compounds in the blood plasma was carried out. Tendency to increase in contents of haemokynes in the mixed saliva and in the tissue samples (from low in the syaloadenopatya to expressed in the syalosis) was revealed. Reduction of thyosulfide index in the blood plasma of these patients was determined. Use of antioxidant remedy in complex treatment of syaloadenopatya and syalosis was substanciated in this paper.
Assuntos
Antioxidantes/uso terapêutico , Doenças das Glândulas Salivares , Adulto , Idoso , Biópsia , Quimiocinas/metabolismo , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Proteína Dissulfeto Redutase (Glutationa)/sangue , Saliva/metabolismo , Doenças das Glândulas Salivares/tratamento farmacológico , Doenças das Glândulas Salivares/metabolismo , Doenças das Glândulas Salivares/patologia , Glândulas Salivares/metabolismo , Glândulas Salivares/patologia , Resultado do TratamentoRESUMO
The pharmacological effect of hydroxyapatite and a composition based on it in the form of Stimulos sponge has been studied in human osteogenic tissue culture. Hydroxyapatite stimulated the biosynthetic processes in the cells. Addition of chlorohexidine and thymogen to the composition in order to increase its antibacterial activity did not decrease the osteoinductive properties of the drug. Trials of Stimulos in 66 patients with chronic generalized periodontitis demonstrated its high efficacy, particularly of the compositions containing immunostimulants: inflammation disappeared and the height of alveolar osseous tissue increased, as did bone compactness.
Assuntos
Adjuvantes Imunológicos/uso terapêutico , Anti-Infecciosos Locais/uso terapêutico , Materiais Biocompatíveis/uso terapêutico , Clorexidina/uso terapêutico , Colágeno/uso terapêutico , Dipeptídeos , Durapatita/uso terapêutico , Peptídeos/uso terapêutico , Periodontite/tratamento farmacológico , Adulto , Processo Alveolar/efeitos dos fármacos , Animais , Doença Crônica , Técnicas de Cultura , Combinação de Medicamentos , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Feminino , Feto , Humanos , Masculino , Pessoa de Meia-Idade , Osteogênese/efeitos dos fármacos , SuínosRESUMO
Experiments on white rats revealed that introduction of Ossocol, a sponge with a composition of hydroxyl apatite with collagen, into a removed tooth well prevented mandibular atrophy and was conducive to a more smooth defect filling with better compact bone tissue. Ossocol use in 214 patients with bone tissue defects developing after tooth removal, of odontogenic cysts, sequestra, and after radical surgery for periodontal diseases demonstrated a positive effect of this agent on the course of the postoperative period: the defect was more rapidly replaced by bone tissue. No unfavorable local or general reactions to Ossocol implantation were observed.
Assuntos
Substitutos Ósseos/uso terapêutico , Colágeno/uso terapêutico , Durapatita/uso terapêutico , Adolescente , Adulto , Animais , Regeneração Óssea/efeitos dos fármacos , Substitutos Ósseos/farmacologia , Colágeno/farmacologia , Contraindicações , Combinação de Medicamentos , Avaliação de Medicamentos , Avaliação Pré-Clínica de Medicamentos , Durapatita/farmacologia , Feminino , Humanos , Masculino , Mandíbula/patologia , Mandíbula/cirurgia , Pessoa de Meia-Idade , Ratos , Ratos Wistar , Fatores de Tempo , Extração Dentária/métodosRESUMO
Synthetic hydroxylapatite, a drug made in this country, enhanced reparative osteogenesis if introduced in the dental well of a white rat. The regenerate represented solid bone structure in 4 months after tooth removal.
