EEG-Validated Photobiomodulation Treatment of Dementia-Case Study.

In this article, we perform a case study of the impact of photobiomodulation (PBM) on brain power spectrum and connectivity in an elderly person with a Self Administered Gerocognitive Exam (SAGE) score indicating probable memory and thinking disorder. First, we designed and realized the prototype of a near-infrared (NIR) device for PBM. Analysing the alpha band of the power spectrum, we found a positive long-term effect in nine out of sixteen electrodes in the eyes-open condition (OE) and in twelve out of sixteen electrodes in the eyes-closed condition (CE), while in the theta band, a positive long-term effect was found in nine out of sixteen electrodes for OE and seven out of sixteen electrodes for CE. When considering the theta-alpha ratio (TAR), the positive long-term effect is found on thirteen of sixteen electrodes for OE and on fourteen of sixteen electrodes for CE. A connectivity analysis using the imaginary component of the complex Pearson correlation coefficient (imCPCC) was also performed, and a global efficiency measure based on connectivity matrices with thresholds was calculated. The global efficiency calculated for the long-term effect was higher than before stimulation by a factor of 5.24 for the OE condition and by a factor of 1.25 for the CE condition. This case study suggests that PBM could have positive effects on improving desired brain activity, measured as improvement in power spectrum and connectivity measures in theta and alpha bands, for elderly people with memory and thinking disorders.

Dynamic Connectivity Analysis Using Adaptive Window Size.

In this paper, we propose a new method to study and evaluate the time-varying brain network dynamics. The proposed RICI-imCPCC method (relative intersection of confidence intervals for the imaginary component of the complex Pearson correlation coefficient) is based on an adaptive window size and the imaginary part of the complex Pearson correlation coefficient. It reduces the weaknesses of the existing method of constant sliding window analysis with narrow and wide windows. These are the low temporal precision and low reliability for short connectivity periods for wide windows, and high susceptibility to noise for narrow windows, all resulting in low estimation accuracy. The proposed method overcomes these shortcomings by dynamically adjusting the window width using the RICI rule, which is based on the statistical properties of the area around the observed sample. In this paper, we compare the RICI-imCPCC with the existing constant sliding window analysis method and describe its advantages. First, the mathematical principles are established. Then, the comparison between the existing and the proposed method using synthetic and real electroencephalography (EEG) data is presented. The results show that the proposed RICI-imCPCC method has improved temporal resolution and estimation accuracy compared to the existing method and is less affected by the noise. The estimation error energy calculated for the RICI-imCPCC method on synthetic signals was lower by a factor of 1.22 compared to the error of the constant sliding window analysis using narrow window size imCPCC, by a factor of 2.87 compared to using wide window size imCPCC, by a factor of 6.69 compared to using narrow window size wPLI, and by a factor of 4.72 compared to using wide window size wPLI. Analysis of the real signals shows the ability of the proposed method to detect a P300 response and to detect a decrease in dynamic connectivity due to desynchronization and blockage of mu-rhythms.

Complex Pearson Correlation Coefficient for EEG Connectivity Analysis.

In the background of all human thinking-acting and reacting are sets of connections between different neurons or groups of neurons. We studied and evaluated these connections using electroencephalography (EEG) brain signals. In this paper, we propose the use of the complex Pearson correlation coefficient (CPCC), which provides information on connectivity with and without consideration of the volume conduction effect. Although the Pearson correlation coefficient is a widely accepted measure of the statistical relationships between random variables and the relationships between signals, it is not being used for EEG data analysis. Its meaning for EEG is not straightforward and rarely well understood. In this work, we compare it to the most commonly used undirected connectivity analysis methods, which are phase locking value (PLV) and weighted phase lag index (wPLI). First, the relationship between the measures is shown analytically. Then, it is illustrated by a practical comparison using synthetic and real EEG data. The relationships between the observed connectivity measures are described in terms of the correlation values between them, which are, for the absolute values of CPCC and PLV, not lower that 0.97, and for the imaginary component of CPCC and wPLI-not lower than 0.92, for all observed frequency bands. Results show that the CPCC includes information of both other measures balanced in a single complex-numbered index.