[Influence of lead on metabolism of vitamins B group in alimentary iron deficient rats]. / Vliianie svintsa na obmen vitaminov gruppy B pri alimentarnoí nedostatochnosti zheleza u krys.

Experimentally induced lead poisoning especially under simultaneous iron deficit leads to the development of secondary thiamine insufficiency. Erythrocyte riboflavin content and erythrocyte glutathion reductase and aspartate aminotransferase activities have been demonstrated to be increased. Lead treatment is accompanied with the increase of urinary excretion of riboflavin, 4-pyridoxic acid and 1-vtthylnicotinamide in rats fed with adequate diet. Thus lead intoxication and iron deficiency influence vitamin B group metabolism.

[Vitamin and mineral status of the population living in the Sverdlovsk region]. / Obespechennost' vitaminami i nekotorymi mineral'nymi élementami naseleniia Sverdlovskoi oblasti.

It was found that low nutritional status for vitamin C, B2, beta-carotene, selenium and calcium are most prominent nutritional problem for population of Sverdlovskaja region of Russia. Level of calcium in serum was low in 50% of examined population. The results suggest the necessity of dietary intake and food contamination assessments for this population.

[Effects of iron deficiency on toxic action of nitrites and endogenous synthesis of N-nitrosamines]. / Vliianie defitsita zheleza na toksicheskoe deistvie nitritov i éndogennyi sintez N-nitrozoaminov.

Separate or joint ingestions of water solutions of sodium nitrite and/or N-diethylamine by rats fed iron deficiency diet caused sharp increasing of N-nitrosodiethylamine level in stomach, a decreasing of Hb and increasing of MetHb concentrations in blood of animal. These effects were greater on iron deficient diet than on control diet. The nitrite ingestion caused a decline level of cytochrome P-450 and inhibition of lipid peroxidation in rat liver.

[Selenium status of the inhabitants in the Kaluga region]. / Obespechennost' selenom zhitelei Kaluzhskoi oblasti.

The human Se status of 8 areas of Kaluga region was studied. The mean serum Se levels 94 mg/l was significantly lower in the south compared to the northern area 126 mg/l. Areas with radioactive pollution possessed higher percentage of persons with low serum Se concentration than in regions without the pollution. Negative influence of radiation on serum Se level was confirmed also by epidemiological data for workers of Chernobil NNP (65 mg/l-workers attending to the reactor and 69 mg/l-for other employees). The same phenomenon was observed for males of Tula region who had taken part in the liquidation of an accident on the Chernobil NNP compared to other inhabitants of Tula region (78 mg/l and 89 mg/l correspondingly). The lowest antioxidant status (serum vitamin E, C and Se concentrations) in towns of Kaluga region with radioactive pollution possessed males of less than 60 years old.

[Effects of selenium on endogenous synthesis of N-nitrosamines and toxicity of nitrites in rats]. / Vliianie selena na éndogennyi sintez N-nitrozaminov i toksicheskoe deistvienitritov u krys.

Male Wistar rats were fed selenium (0.2, 2.9 or 5.5 mg/kg of dry feed) in the form of selenomethionine. They also received for 6 weeks amidopyrine (33 mg/kg b.w.) and/or sodium nitrite (20 mg/kg b.w.) administered intragastrically. The quantitation of endogenously synthetized volatile nitrosamines in the stomach, selenium in the serum, biochemically evaluated nitrite and nitrosamines toxicity revealed an inverse relationship between feed selenium concentrations and the amount of endogenously produced nitrosodimethylamine from equal precursor doses. A protective selenium effect on methemoglobin-producing action of nitrite ions was established. It is shown that introduction of precursors induces increased body need in selenium.

[Effect of nitrates on the dynamics of methemoglobin formation in rats of various ages]. / Vliianie nitratov na dinamiku metgemoglobinoobrazovaniia u krys razlichnykh vozrastnykh grupp.

Wistar male rats with body mass of 50-83 g and 327-365 g were treated per os with solution of sodium nitrate in single dose of 500 or 1000 mg/kg of body mass (on the base of nitrate-ion). The level of methemoglobin (MH) and activity of methemoglobinreductase (MHR) in blood were analyzed. It was shown that level of MH in blood of young immature rats was increased with appearance of two peaks after ingestion both doses of nitrate. The appearance of two peaks of MH in mature rats was observed only after the high dose of nitrate. Low dose of nitrate caused increase of MH concentration only one time. Both doses of nitrate did not effect on MHR activity in rat blood.