RESUMO
BACKGROUND: Frailty syndrome is common among older people and can lead to various adverse consequences such as falls, cognitive decline, disability, dependent living, increased mortality, excessive drug use, and prolonged hospital stays. OBJECTIVES: This research determined the prevalence of frailty and associated factors among older adults in Vietnam. METHODS: A cross-sectional study was conducted on 584 older adults across five Ho Chi Minh City wards from November 2020 to January 2021. Based on the modified Fried frailty scale, the participants were divided into three categories: robust, pre-frail, and frail. A chi-square test (or Fisher's test) examined the relationship between frailty categories and other variables. Multivariable logistic regression used variates with a cut-off of p ≤ 0.05 in the univariate analysis. RESULTS: The prevalence rates of frailty and pre-frailty were 19% and 64%, respectively. The most common frailty component was weak grip strength (63.9%), followed by slowness (36.1%), weight loss (21.6%), low physical activity (19.5%), and exhaustion (18.5%). In addition, the prevalence of frailty was significantly associated with age, BMI levels, living alone, and sarcopenia. CONCLUSION: The community's prevalence of frailty among older adults is high. Frailty can lead to many adverse consequences for the elderly. As there were some modifiable factors associated with frailty, it should be assessed in older people through community-based healthcare programs for early diagnosis and management.
RESUMO
A widely used herbicide for controlling weeds, glyphosate, is causing environmental pollution. It is necessary to remove it from environment using a cost-effective and eco-friendly method. The aims of this study were to isolate glyphosate-degrading bacteria and to optimize their degradative conditions required for bioremediation. Sixteen bacterial strains were isolated through enrichment and one strain, Rhodococcus soli G41, demonstrated a high removal rate of glyphosate than other strains. Response surface methodology was employed to optimize distinct environmental factors on glyphosate degradation of G41 strain. The optimal conditions for the maximum glyphosate degradation were found to have the NH4Cl concentration of 0.663% and glyphosate concentration of 0.115%, resulting in a maximum degradation of 42.7% after 7 days. Bioremediation analysis showed 47.1% and 40% of glyphosate in unsterile soil and sterile soil was removed by G41 strain after 14 days, respectively. The presence of soxB gene in G41 strain indicates that the glyphosate is degraded via the eco-friendly sarcosine pathway. The results indicated that G41 strain has the potential to serve as an in-situ candidate for bioremediation of glyphosate polluted environments.
