[Vein of Galen aneurysmal malformation]. / Malformace Galenovy zíly u plodu.

OBJECTIVE: A case report of the pregnancy complicated by the presence of vein of Galen aneurysmal malformation in fetus. DESIGN: The case report. SETTING: Department of Obstetrics and Gynaecology, Masaryks Hospital, Jilemnice; Obstetrics and Gynecology Clinic, University Hospital in Hradec Králové. CASE REPORT: The description of the pregnancy complicated by the presence of vein of Galen aneurysmal malformation in a fetus 32 weeks gestation which led to a progressive heart failure and the development of the hydrocephalus. CONCLUSION: The vein of Galen aneurysmal malformation is a rare cerebrovascular malformation of the fetus, the diagnosis of this malformation is usually detectable during prenatal ultrasound examination possibly also by magnetic resonance imaging.

[3D MRI-based brachytherapy in patients with locally advanced cervical carcinoma - early clinical results]. / 3D MR-based brachyterapie v lécbe lokálne pokrocilého karcinomu delozního hrdla - casné klinické výsledky.

OBJECTIVE: To demonstrate the clinical benefit of MRI-based brachytherapy using CT and MRI data fusion. DESIGN: Clinical trial. SETTING: Oncology Centre, Multiscan and Pardubice Regional Hospital, Pardubice. METHODS: Thirty six patients with locally advanced cervical cancer were treated with MRI-based brachytherapy (MRI-based preplanning 15 patients, MRI approximation 21 patients). All patients were continuously followed during and after treatment. Tumor control and toxicity were evaluated at each visit. Late gastrointestinal and genitourinary symptoms were recorded, using Fox Chase (FC) modification of the Radiation Therapy Oncology Group (RTOG) and Late Effects Normal Tissue Task Force (LENT) toxicity criteria. RESULTS: We observed no complications during the entire MRI procedure at the radiology department. The cumulative incidence of grade 2 late genitourinary and gastrointestinal toxicity at median follow up of 30.3 months was 4.8% and 9.5% for MRI approximation, respectively 0% and 13.3% for MRI-based preplanning. Local control was 86.7% for MRI-based preplanning and 76.2% for MRI approximation. CONCLUSION: 3D MRI-based brachytherapy with consecutive CT/MRI data fusion yields excellent local control with minor toxicity.