RESUMO
We investigated the effect of Thymostimulin (TP-1) (a bovine thymic extract) on some clinical and immunological parameters in hospitalized aged humans. Forty aged patients were randomized into two groups, one received no therapy and the other was treated with TP-1 for 3 mth. The Ig and complement levels, sheep rosette-forming cells, absolute lymphocyte numbers and sedimentation rate were measured on days 0, 90 and 180. Moreover, the incidence of infections was determined. The baseline immunological data of the patients studied were within the normal range. These data remained unchanged after TP-1 treatment. In the TP-1 treated group we observed a significant reduction of infections (P=0.023) in comparison to the control group. A significant reduction of the sedimentation rate was also observed in the treated group.
Assuntos
Envelhecimento , Imunidade Celular/efeitos dos fármacos , Controle de Infecções , Linfócitos T/efeitos dos fármacos , Extratos do Timo/administração & dosagem , Idoso , Animais , Sedimentação Sanguínea , Proteínas do Sistema Complemento/análise , Humanos , Imunoglobulinas/análise , Infecções/imunologia , Contagem de Leucócitos , Linfócitos/efeitos dos fármacos , Formação de Roseta , Ovinos , Extratos do Timo/uso terapêuticoRESUMO
Thirty patients with herpetic keratitis, recurrent in 17, were examined and submitted to an immunological evaluation for cell-mediated immunity (E rosette forming cells, absolute number of T lymphocytes, skin tests). A group of 15 patients was treated with Levamisole (2.5 mg/kg body weight, 3 days a week), while the control group received no Levamisole. The observation period varied from 6 to 24 months. The clinical follow-up showed a reduction in the severity and duration of herpetic attacks and in the frequency of relapses compared with the control group. The immunological findings indicated a normalization of E rosettes in all the patients (treated and controls).