RESUMO
Aminotransferase levels in the peripheral blood serum of African green monkeys were studied after aerosol infection with lyophilized virus preparation. A correlation between aminotransferase activity and other symptoms of hemorrhagic fever was shown. Considerable variations in the features of aminotransferase activity in severe and mild cases of the disease were observed.
Assuntos
Alanina Transaminase/sangue , Aspartato Aminotransferases/sangue , Ensaios Enzimáticos Clínicos , Doença do Vírus de Marburg/diagnóstico , Animais , Chlorocebus aethiops , Fígado/enzimologia , Fatores de Tempo , Viremia/diagnósticoRESUMO
A comparative study on the features of the pathogenesis of Marburg disease after parenteral and aerosol infection of green monkeys with a virus prepared from native culture suspension and that after lyophilization was carried out. The changes in the dynamics of the clotting time, the activity of serum aminotransferases, the duration of prefebrile period and survival time were analysed in different cases. No lethality was observed in animals infected with small doses of aerosol preparations.