[Radiofrequency ablation in comprehensive surgical treatment of patients with varicose veins of lower limbs]. / Radiochastotnaia obliteratsiia v kompleksnom khirurgicheskom lechenii bol'nykh s varikoznoi bolezn'iu nizhnikh konechnostei.

Analysed herein are the results of using radiofrequency ablation (RFA) in comprehensive surgical treatment of patients presenting with varicose veins of the lower extremities. The study included a series of ninety-eight 28-to-60-year-old patients (with a total of 105 operations performed) suffering from varicose veins of the lower limbs. Of these, there were 10 men (10.3%) and 88 women (89.7%). Venous disease of clinical class C2 according to the CEAP classification was diagnosed in 80 patients, that of class C3 in 17, and that of class C4a in 1 patient. The procedure of RFA was performed by means of the VNUS device model RF62. The impact was exerted in an automatic mode, maintaining the catheter's temperature at 120° C during a 20-second treatment cycle for each 7 cm of the vein's length. In all cases, each 7-cm-long venous segment to be treated was acted upon 4 times. Forty-five patients after RFA underwent ultrasonographic monitoring performed first on POD 7 and then at 3, 6, 12 and 24 months. Recanalization of the trunk of the great saphenous vein (GSV) was registered in 3 (2.8%) cases at terms up to 3 months after the operation. In 2 cases recanalization turned out to be provoked by an incompetent perforant vein in the lower third of the femur. Seven (6.6%) patients with a large diameter of the great saphenous vein were found to develop post-closure hyperpigmentation which resolved spontaneously 8 months later. The remaining patients, with strict adherence to the indications for RFA, demonstrated complete obliteration of the vessel treated, with no recanalization observed ultrasonographically 10-12 months after the procedure. An additional experimental study with a morphological analysis confirmed appropriateness of carrying out four 20-second treatment cycles of RFA in each segment of the vein. A conclusion was made that RFA used in comprehensive surgical treatment for varicose veins of the lower limbs makes it possible to attain good therapeutic and cosmetic results that persist over time, if conducted in compliance with the mentioned fundamentally essential peculiarities of performing the procedure.

[CLINICAL EFFICACY AND SAFETY OF LITHOLYTIC THERAPY WITH LIVODEXA IN PATIENTS WITH CHRONIC CHOLECYSTITIS AND BILIARY SLUDGE].

The authors present their own experience litholytic therapy of 68 patients with chronic cholecystitis and biliary sludge using the Livodexa (Sun Pharmaceutical Industries Ltd, India) at 12 and 24-week course of treatment. In a prospective 24-week investigation was estimated decrease in biliary sludge in the gallbladder as an integral indicator of the effective ness of litholytic therapy and decline of adverse event during treatment, as an indicator of the safety of treatment.

[The prognostic significance of cholesterol determination in the high-density lipoprotein fraction of blood donors]. / Prognosticheskaia znachimost' opredeleniia kholesterina vo fraktsii lipoproteidov vysokoi plotnosti u donorov krovi.

The relationships between concentrations of HDLP cholesterol and total cholesterol (TC), triglycerides in the blood serum; between HDLP cholesterol content and TC have been analyzed in the group of blood donors. Three variants were determined: 1) high TC, normal HDLP cholesterol, low HDLP proportion in TC 2) high TC, high HDLP cholesterol, normal HDLP/TC 3) normal TC, low HDLP cholesterol, low proportion of HDLP in TC. There were no correlations between HDLP cholesterol and triglycerides quantities in the blood serum.

[Photoluminescence band and anti-Stokes emission of native collagen in the visible range of the spectrum]. / Polosa fotoliuminestsentsii i antistoksovo izluchenie nativnogo kollagena v vidimoi oblasti spectra.

Photoluminescence (PL) of collagen, phenylalanine and tyrosine has been experimentally studied in the range of 400-700 nm. Anti-Stokes emission was observed when PL was excited by visible light. Possible participation of an excimer in generation of PL was shown. It has been pointed out that phenylalanine chromophore plays a dominant role in fluorescence generation of collagen in the spectrum visible range.