RESUMO
A series of new tropan derivatives have been synthesized and investigated, which can both weaken and potentiate the serotonin-induced cerebrovascular constrictory reactions. The compound LK-728 produces a pronounced antiserotonin cerebrovascular action comparable to that of tropoxin, but being superior to the reference drug in the effect duration. On the contrary, another tropan derivative LK-769 enhances the cerebrovascular response to serotonin. A similar effect was demonstrated with the well-known antimigraine agent sumatriptan, which is an agonist of 5HT1B/1D receptors. The ability of sumatriptan to increase the local cerebral blood flow which was observed in our experiments, may also play an important role in the mechanism of the antimigraine action produced by this serotonin receptor agonist.
Assuntos
Circulação Cerebrovascular/efeitos dos fármacos , Antagonistas da Serotonina/farmacologia , Agonistas do Receptor de Serotonina/farmacologia , Serotonina/metabolismo , Tropanos/farmacologia , Vasoconstritores/farmacologia , Animais , Compostos Aza/farmacologia , Compostos Bicíclicos Heterocíclicos com Pontes/farmacologia , Masculino , Ratos , Agonistas do Receptor 5-HT1 de Serotonina , Antagonistas do Receptor 5-HT2 de Serotonina , Sumatriptana/farmacologia , Triptaminas/farmacologia , Triptaminas/uso terapêuticoRESUMO
Comparative study of the immune sera from rabbits immunized with both formol and native cardiotoxins, cardiotoxin incorporated into sphingomyelin-phosphatidylcholine-cholesterol liposome stabilized with osmium tetroxide, and a cardiotoxin-succinylated bovine albumin conjugate was performed. The latter produced antibodies identified by immunodiffusion assay. The highest survival was observed in animals treated with antiserum to cardiotoxin-albumin conjugate, followed by antitoxin to combination of formol and native cardiotoxins. Antiserum to cardiotoxin in liposome was ineffective.
