Assuntos
Hipóxia/diagnóstico por imagem , Imagem Multimodal , Placa Aterosclerótica/diagnóstico por imagem , Idoso , Meios de Contraste , Complexos de Coordenação , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Compostos Organometálicos , Placa Aterosclerótica/cirurgia , Tomografia por Emissão de Pósitrons , Estudos Prospectivos , TiossemicarbazonasRESUMO
For PET radionuclides, the radioactivity of a sample can be conveniently measured by a dose calibrator. These devices depend on a "calibration setting number", but many recommended settings from manuals were interpolated based on standard sources of other radionuclide(s). We conducted HPGe gamma-ray spectroscopy, resulting in a reference for determining settings in two types of vessels containing one of several PET radionuclides. Our results reiterate the notion that in-house, experimental calibrations are recommended for different radionuclides and vessels.
Assuntos
Tomografia por Emissão de Pósitrons/estatística & dados numéricos , Tomografia por Emissão de Pósitrons/normas , Radioisótopos/análise , Radiometria/estatística & dados numéricos , Radiometria/normas , Radioisótopos de Bromo/análise , Calibragem , Radioisótopos de Cobre/análise , Humanos , Radioisótopos do Iodo/análise , Manganês/análise , Radioisótopos de Ítrio/análise , Zircônio/análiseRESUMO
Hypoxia imaging has applications in functional recovery in ischemic events such as stroke and myocardial ischemia, but especially in tumors in which hypoxia can be predictive of treatment response and overall prognosis. Recently there has been development of imaging agents utilizing positron emission tomography for non-invasive imaging of hypoxia. Many of these PET agents have come to the forefront of hypoxia imaging. Halogenated PET nitroimidazole imaging agents labeled with (18)F (t(1/2) = 110 m) and (124)I (t(1/2) = 110 m) have been under investigation for the last 25 years, with radiometal agents ((64)Cu-ATSM) being developed more recently. This review focuses on these positron emission tomography imaging agents for hypoxia.
