[Suppressive effect of circulating immune complexes on cytotoxicity of blood lymphocytes in patients with chronic myeloid leukemia]. / Supressivnoe deistvie tsirkuliruiushchikh immunnykh kompleksov na tsitotoksichnost' limfotsitov krovi bol'nykh khronicheskim mielo- leikozom.

Concentration of circulating immune complexes (CIC) and cytotoxicity (natural and antibody-dependent) of blood lymphocytes were studied in 52 patients at the developed stage of chronic myeloid leukemia (CML). Elevation of CIC level and reduction of cytotoxicity detectable in all CML patients were most manifest in those with high tumor mass and during exacerbation of the leukemia process. A conclusion has been made that CIC are suppressors of natural and antibody-dependent cytotoxicity of blood lymphocytes in CML patients.

[Circulating immune complexes and neutrophilic phagocytic function in patients with idiopathic autoimmune thrombocytopenic purpura]. / Tsirkuliruiushchie immunnye kompleksy i fagotsitarnaia funktsiia neitrofilov u bol'nykh idiopaticheskoi autoimmunnoi trombotsitopenicheskoi purpuroi.

The concentration of circulating immune complexes, serum immunoglobulins and state of phagocytic function of neutrophils was studied in patients with autoimmune thrombocytopenic purpura. The patients showed a significant increase of the levels of circulating immune complexes, content of Ig M and Ig G, an increase of the phagocytic activity of neutrophils at the stage of migration, adhesion and absorption of the heterogeneous. The revealed disorders of phagocytic function and destruction of granulocytes at the stage of digestion may be explained by increased load on the phagocytic neutrophils due to the main pathologic process.

[The levels of circulating immune complexes and immunoglobulins in patients with systemic lupus erythematosus and rheumatoid arthritis]. / Urovni tsirkuliruiushchikh immunnykh kompleksov i immunoglobulinov u bol'nykh sistemnoi krasnoi volchankoi i revmatoidnym artritom.

UNLABELLED: The authors studied the levels of large- and medium molecular circulating immune complexes (CIC) and immunoglobulins of main classes (Ig) in 17 patients with systemic lupus erythematosus (SLE) and 47 patients with rheumatoid arthritis (RA). RESULTS: low molecular CIC increased in 35.2% of patients with SLE and in 42.5% with RA; patients with SLE showed a significant reduction of IgA in 80.4%. The IgA/IgM ratio was significantly reduced in SLE due to the above finding. The IgA level remained unchanged in RA.