[Sertraline in child and adolescent psychiatry]. / Primenenie sertralina v detskoi i podrostkovoi psikhiatrii.

The aim of the study was to research the efficiency of sertraline (zoloft) in depressions, anxious states and obsessive-compulsive disorders. Diagnosis of the mental disorders was carried out according to ICD-10. 72 children (59 boys, 13 girls) aged 6-18 years were treated. There were 32 inpatients and 40 outpatients. Therapy with sertraline was performed during 8 weeks with a gradual increase (titration) and individual selection of the dose from 12.5 to 100 mg/day. During the therapy clinical observation was combined with the patients' examination using Hamilton Depression Scale and Hamilton Anxiety Scale (HAM-D and HAM-A), and a Clinical Global Impression Scale (CGI). It was established that sertraline was very effective and safe drug in children (it has no influence on cognitive functions, has neither myorelaxing or sedative effects). Activity of this drug is characterized by quick manifestation of thymoanaleptic and anxiolytic effects. It mild depressive states 50 mg/day is a significant dose; in more severe depressions and obsessive-compulsive disorders the dose in juveniles was to 100 mg, the duration of the therapy was more than 2 months.

[Asthenic disorders in sailors during long sea voyages]. / Astenicheskie rasstroistva u moriakov v period dlite'lnykh reisov.

The peculiarities of asthenic disorders formation in sailors under long-lasting sail were shown to depend on prevalent extremal factors. Clinico-psychopathological and psychological investigation allowed the author to single out 4 groups of asthenia (psychogenic, psychosomatic+, somatogenic and cerebrogenic). Nonpathological premorbid and morbid variants are described with the course of their psychological and autonomic indices. The data can be used for professional selection to detect groups at high risk of neurotic disorders and for designing the differentiated system of prevention and correction.