In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. against yeasts.

In vitro antifungal activity of phenylheptatriyne from Bidens cernua L. (Asteraceae) was studied using broth macrodilution method against 125 strains of yeasts including 104 clinical and other isolates of Candida spp. (C. albicans, C. krusei, C. tropicalis, C. guilliermondii, C. parapsilosis, C. glabrata, C. inconspicua), 16 strains of basidiomycetous yeasts (Cryptococcus neoformans, C. albidus, Trichosporon cutaneum, Rhodotorula glutinis) and five standard reference strains of Candida species. Phenylheptatriyne has shown significant activity against investigated strains, and the Minimal Inhibitory Concentrations for Candida spp. were determined as 12.5-50 microg/ml and for basidiomycetous yeasts as 12.5-100 microg/ml.

[Antioxidant effect of the antineoplastic antibiotic obtained from a plant of the family Asteraceae]. / Antioksidantnoe deistvie protivoopukholevogo antibiotika, poluchennogo iz rasteniia semeistva slozhnotsvetnykh.

Antitumour antibiotic from a plant of the family Asteracea has been studied for the biochemical mechanism of its action. Redox processes were tested by the method of spontaneous chemiluminescence determining the intensity of freely radical oxidation of membrane cell phospholipids. It was established that the antibiotic under study stabilized the indices of spontaneous chemiluminescence up to the normal level.