Updating navigation with intraoperative image data.

OBJECTIVES: To localize overlooked tumor remnants by updating navigation with intraoperative magnetic resonance imaging compensating for the effects of brain shift. METHODS: In 112 patients among 805 patients that were investigated by combined use of intraoperative high-field (1.5 T) magnetic resonance imaging and navigation, mostly glioma cases (n = 85), an update of the navigation was performed. Intraoperative image data were rigidly registered with the preoperative image data, the tumor remnant was segmented, and then the initial patient registration was restored so that the registration coordinate system of the preoperative image data was applied on the intraoperative images, allowing navigation updating without intraoperative patient re-registration. RESULTS: Navigation could be updated reliably in all cases. Potential positional shifting impairing the initial update strategy was observed only in 2 cases so that a patient re-registration was necessary. The target registration error of the initial patient registration was 1.33 +/- 0.63 mm, and registration of preoperative and intraoperative images could be performed with high accuracy, as proven by landmark checks. Updating of navigation resulted in increased resections or correction of a catheter position or biopsy sampling site in 94%. In the remaining 7 patients, the intraoperative images were used for correlation with the surgical site but without changing the surgical strategy. CONCLUSIONS: Navigation can be reliably updated with intraoperative image data without repeated patient registration, facilitating the update procedure. Updated navigation allows achieving enlarged resections and compensates for the effects of brain shift.

Application accuracy of automatic registration in frameless stereotaxy.

OBJECTIVE: We compared the application accuracy of an infrared-based neuronavigation system when used with a novel automatic registration with its application accuracy when standard fiducial-based registration is performed. METHODS: The automatic referencing tool is based on markers that are integrated in the headrest holder we routinely use in our intraoperative magnetic resonance imaging (MRI) setting and can be detected by the navigation software automatically. For navigation targeting we used a Plexiglas phantom with 32 notched rods of different heights. The phantom was fixed in the head holder and multiple optimized gradient echo slices containing the clamp-integrated markers were acquired. After that we measured a T1 MPRAGE sequence with a slice thickness of 1.0 mm for navigation. The deepest points of the surface of the rods were defined as target points in image space. In three measurement series we referenced the phantom once with 4, once with 7 fiducials and twice automatically. In one series we performed only one automatic registration. The localization error was measured 3 times per rod and registration. RESULTS: The median localization errors for standard registration with 7 fiducials were between 1.2 and 3.05 mm. With 4 fiducials, medians were in the range from 1.87 to 2.21 mm. For the automatic registration we obtained median localization errors between 0.88 and 2.13 mm. In 6 of the 8 samples that were compared the automatic registration showed an application accuracy that was highly significantly better (p < 0.001 in most cases) than that of fiducial-based standard registration. CONCLUSION: The application accuracy found for automatic referencing is at least not worse than that for standard registration no matter whether 4 or 7 fiducial markers were used. Therefore, its use in the operating room is feasible. In combination with intraoperative MRI it may become a favorable alternative to standard fiducial-based registration especially when an intraoperative update of navigation data is necessary.

Intraoperative high-field magnetic resonance imaging in transsphenoidal surgery of hormonally inactive pituitary macroadenomas.

OBJECTIVE: The aim of the study was to evaluate the effect of intraoperative, high-field (1.5 T) magnetic resonance imaging (MRI) on the results of transsphenoidal surgery of hormonally inactive pituitary macroadenomas. METHODS: One hundred six patients (tumor size, 29.9 +/- 10.1 mm; minimum, 11.3 mm; maximum, 57.2 mm) with hormonally inactive pituitary macroadenoma were investigated by intraoperative high-field MRI during transsphenoidal surgery. If intraoperative imaging depicted an accessible tumor remnant, resection was continued. RESULTS: Among the 85 patients in whom complete tumor removal was intended preoperatively, intraoperative imaging revealed definite tumor remnants or suspicious findings in 36 (42%) patients. Imaging led to an extended resection in 29 (34%) patients of this group. Among them, resection could be completed in 21. This increased the rate of complete tumor removal from 58% (49 out of 85) to 82% (70 out of 85). In the group of patients with intended partial removal (n = 21), resection was extended in 38% (eight out of 21) because of intraoperative imaging. Comparison with scanning 3 months after surgery did not reveal any false-negative findings of intraoperative MRI; in six cases, intraoperative MRI was suspicious for some minor remnant that could not be reproduced in the postoperative control. CONCLUSION: The extent of resection in transsphenoidal surgery can be reliably assessed using intraoperative high-field MRI. In addition to the suprasellar compartment, intra- and parasellar structures are also visualized in great detail. Intraoperative imaging acts as an immediate intraoperative quality control, allowing one to not only increase the extent of resection, but to also increase the percentage of complete removals.

Intraoperative high-field-strength MR imaging: implementation and experience in 200 patients.

PURPOSE: To review the initial clinical experience with intraoperative high-field-strength magnetic resonance (MR) imaging of brain lesions in 200 patients. MATERIALS AND METHODS: Two hundred patients (mean age, 46.1 years; range, 7-84 years), most of whom had glioma or pituitary adenoma, were examined with a 1.5-T MR imager equipped with a rotating operating table and located in a radiofrequency-shielded operating theater. A navigation microscope placed inside the 0.5-mT zone and used in combination with a ceiling-mounted navigation system enabled integrated microscope-based neuronavigation. The extent of resection depicted at intraoperative imaging, the surgical consequences of intraoperative imaging, and the clinical practicability of the operating room setup were analyzed. RESULTS: Seventy-seven resections with a transsphenoidal approach, 100 craniotomies, and 23 burr-hole procedures were performed. In 55 (27.5%) of 200 patients, intraoperative MR imaging had immediate surgical consequences (eg, extension of resection in 39% of patients with pituitary adenoma or glioma). In 108 patients the navigation system was used, and for 37 of those patients, functional imaging data were integrated into the navigation system. There was nearly no difference in quality between pre- and intraoperative images. Intraoperative workflow with intraoperative patient transport for imaging was straightforward, and imaging in most cases began less than 2 minutes after sterile covering of the surgical site. No complications resulted from high-field-strength MR imaging. CONCLUSION: The high-field-strength MR imager was successfully adapted for intraoperative use with the integrated neuronavigation system. Intraoperative MR imaging provided valuable information that allowed intraoperative modification of the surgical strategy.

Volumetric assessment of glioma removal by intraoperative high-field magnetic resonance imaging.

OBJECTIVE: To investigate the contribution of high-field intraoperative magnetic resonance imaging (iMRI) for further reduction of tumor volume in glioma surgery. METHODS: From April 2002 to June 2003, 182 neurosurgical procedures were performed with a 1.5-T magnetic resonance system. Among patients who underwent these procedures, 47 patients with gliomas (14 with World Health Organization Grade I or II glioma, and 33 with World Health Organization Grade III or IV glioma) who underwent craniotomy were investigated retrospectively. Completeness of tumor resection and volumetric analysis were assessed with intraoperative imaging data. RESULTS: Surgical procedures were influenced by iMRI in 36.2% of operations, and surgery was continued to remove residual tumor. Additional further resection significantly reduced the percentage of final tumor volume compared with first iMRI scan (6.9% +/- 10.3% versus 21.4% +/- 13.8%; P < 0.001). Percentages of final tumor volume also were significantly reduced in both low-grade (10.3% +/- 11.5% versus 25.8% +/- 16.3%; P < 0.05) and high-grade gliomas (5.4% +/- 9.9% versus 19.5% +/- 13.0%; P < 0.001). Complete resection was achieved finally in 36.2% of all patients (low-grade, 57.1%; high-grade, 27.3%). Among the 17 patients in whom complete tumor resection was achieved, 7 complete resections (41.2%) were attributable to further tumor removal after iMRI. We did not encounter unexpected events attributable to high-field iMRI, and standard neurosurgical equipment could be used safely. CONCLUSION: Despite extended resections, introduction of high-field iMRI in conjunction with functional navigation did not translate into an increased risk of postoperative deficits. The use of high-field iMRI increased radicality in glioma surgery without additional morbidity.

Frameless stereotactic surgery using intraoperative high-field magnetic resonance imaging.

This study evaluated the clinical validity of frameless stereotaxy using high-field intraoperative magnetic resonance (iMR) imaging combined with an in-room neuronavigation system. A 1.5 Tesla MR scanner in conjunction with a ceiling-mounted neuronavigation system was used during 32 frameless stereotaxy procedures consisting of 19 brain biopsies and 13 catheter placements between April 2002 and mid-October 2003. Evaluation of the procedure was based on either the rate of histological diagnostic yield or the ability to accurately position the catheter in the target region. This technique allowed successful registration with a mean error of 1.2 +/- 0.8 mm and resulted in successful placement of the instrument within the target tissue. Intraoperatively, frozen section analysis showed all biopsy samples contained pathological tissue and locations of sampling points were confirmed by iMR imaging. Specific final diagnosis was made in all 19 brain biopsies. The tip of the catheter was successfully placed into the target in all 13 patients confirmed by iMR imaging. The catheter was repositioned based on iMR imaging in four of 13 patients, increasing the rate of successful placement. There were no procedure-related neurological deficits or mortality, but we encountered two cases of wound infection, one needing surgical revision. Total additional procedure time related to the induction of iMR imaging was 76.7 +/- 23.3 minutes. This initial experience of the combination of conventional frameless stereotaxy and high-field iMR imaging improved the quality of frameless stereotaxy with low morbidity and mortality, but did not translate into a significant reduction of procedure-related time.