RESUMO
Omeprazole is a proton pump inhibitor widely used in the treatment of gastro-esophageal reflux disease and peptic ulcer disease. In a 73-year-old man we describe renal failure due to acute interstitial nephritis after use of omeprazol during 4 months. Unexpected renal failure without signs of hydronephrosis should always provoke awareness of drug reaction, omeprazole being one of the possible drugs.
Assuntos
Injúria Renal Aguda/etiologia , Inibidores Enzimáticos/efeitos adversos , Nefrite Intersticial/induzido quimicamente , Omeprazol/efeitos adversos , Injúria Renal Aguda/patologia , Injúria Renal Aguda/fisiopatologia , Idoso , Refluxo Gastroesofágico/complicações , Refluxo Gastroesofágico/tratamento farmacológico , Humanos , Masculino , Nefrite Intersticial/complicações , Nefrite Intersticial/patologia , Nefrite Intersticial/fisiopatologia , Recuperação de Função Fisiológica/efeitos dos fármacos , Resultado do TratamentoRESUMO
The purpose of this study was to investigate whether chronic subcutaneous administration of epoetin has an influence on its pharmacokinetics in patients with chronic renal failure and anaemia. 14 Patients were included in the study. The data of 8 patients could be evaluated at the end of the study. All patients were on maintenance haemodialysis. The pharmacokinetic profile of epoetin was studied directly after the first subcutaneous administration of 60 U/kg body weight. Patients were further treated with epoetin to maintain haemoglobin concentration between 6.0 and 6.5 mmol/l. After about one year of treatment the pharmacokinetic profile was studied again, using the same dosage. Between both profiles no significant differences (paired Student's t-test) were found in the pharmacokinetic parameters studied: absorption half-life, time to maximum concentration, maximum concentration, elimination half-life, area under the curve and mean residence time. However, in individual patients large differences may be found.
Assuntos
Eritropoetina/farmacocinética , Diálise Renal , Adulto , Idoso , Idoso de 80 Anos ou mais , Anemia/tratamento farmacológico , Eritropoetina/administração & dosagem , Eritropoetina/uso terapêutico , Feminino , Meia-Vida , Humanos , Injeções Subcutâneas , Falência Renal Crônica/complicações , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Radioimunoensaio , Proteínas Recombinantes/administração & dosagem , Proteínas Recombinantes/farmacocinética , Proteínas Recombinantes/uso terapêutico , Fatores de TempoRESUMO
From January 1981 to September 1983 forty knees had replacement of a torn anterior cruciate ligament with a tendon xenograft. In six of the first thirty knees that were operated on severe synovitis developed within eight months after the operation, and total synovectomy and removal of the graft was required. Because of this complication we changed the recommended rinsing procedure for the graft in the last ten knees, and no synovitis occurred in these. Approximately half of all of the grafts ruptured between twelve and twenty months after the operation.
