[Motor and secretion function of stomach and duodenum, duodenogastric reflux in patients with duodenal ulcer]. / Sekretornaia, motornaia funktsiia zheludka i dvenadtsatiperstnoi kishki, duodenogastral'nyi refliuks u bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki.

Gastric secretion, motor function and tonicity of the stomach and duodenum, duodenogastric reflux were studied in inpatients with two clinicopathogenetic types of duodenal ulcer: observed at young age (type 1) and in later life (type 2). The examination included pH-metry with simultaneous balloon cimography, chromogastroduodenoscopy with Kongo-red, tests for Helicobacter pylori conducted on the biopsy samples. All the patients were found to have continuous acid production. High acid production was more frequently registered in males with the disease type 1, the lowest production was in females with the disease type 2. Duration of the acid inflow into the duodenum in patients with the disease type 2 was greater than that in young subjects. Mild ulcer was associated with moderate acidity in the duodenum, in severe ulcer the acidity was very high. Males with the disease 1 and 2 and females with type 2 had hyperkinetic, hypertonic gastric motor function. In duodenal ulcer prevalent is hypertonic, hyperkinetic type of duodenal motor function being most frequent among males with the disease type 2. Duodenogastric reflux occurs more often in patients with intensive acid production associated with hypotonic, hypokinetic motor type and duodenal tone.

[Duodenogastric reflux in patients with alimentary obesity]. / Duodenogastral'nyi refliuks u bol'nykh s alimentarnym ozhireniem.

The authors analyze findings from a comprehensive clinical and instrumental evaluation of 59 patients presenting with duodenogastric reflux. The above findings suggest that underlying the duodenogastric reflux in those patients having surplus body mass might be hypotonia of the stomach, particularly its pyloric portion. In patients with body mass that do not deviate from physiologic norms regurgitation of bile into the stomach results from the presence of duodenal dyskinesia by hypertonic type. The results obtained suggest that patients with gastroduodenal reflux need treatment options for them to be carefully thought out. The above reflux appeared to be particularly pronounced in those patients presenting with alimentary obesity as per analysis of the gastric content. Patients with grade II obesity show more noticeable tonic disorders of the pyloric portion of the stomach.

[The use of nitrates and slow calcium channel blockers in the treatment of patients with ischemic heart disease and disorders of intraventricular conduction]. / Ispol'zovanie nitratov i blokatorov medlennykh kal'tsievykh kanalov v lechenii bol'nykh ishemicheskoi bolezn'iu serdtsa s narusheniiami vnutrizheludochkovoi provodimosti.

Data are submitted on the condition of haemodynamics of greater and lesser circulation in patients with ischemic heart disease (IHD) presenting with the bundle-branch block. On the basis of the results from a combined clinical-instrumental investigation involving electro- and echocardiography the authors present the early objective quantitative criteria for the diagnosis of those haemodynamic shifts occurring in formation of the bundle-branch block. The blockade of the left bundle of His has a more pronounced effect on the greater circulation haemodynamics while that of the right one--on the lesser circulation. The authors give a comparative assessment of haemodynamic effects of a single dose of isosorbide dindtrate and nifedinin in the patients. Nitrosorbide and corinfar improve contractility of the left ventricle, decrease pulmonary hypertension and overloading of the right side of the heart.

[The role of different investigations in diagnosis of functional disorders of the biliary system]. / Rol' razlichnykh metodov issledovaniia v diagnostike funktsional'nykh rasstroistv v zhelchevyvodiashchei sisteme.

The paper presents the results obtained upon examination of inpatients with various types of biliary dyskinesia. The examination included: fraction chromatic duodenal intubation, stepwise manometry, cholecystography, ultrasound investigation of the liver, gall bladder, biochemical tests of the bile. Fraction duodenal intubation discovered gall bladder dysfunction. The manometry was necessary for diagnosis of duodenal hypertension. X-ray revealed primary defects in gall bladder motility. It is concluded that the diagnosis of functional disorders implies combined clinical and instrumental modalities.

[Dynamics of biliary prostaglandin secretion in patients with dyskinesia of the biliary tracts]. / Dinamika vydeleniia prostaglandinov s zhelch'iu u bol'nykh diskineziei zhelchevyvodiashchikh putei.

The time course of biliary secretion of prostaglandins (PG)E1 and F2 alpha was studied in 20 patients with primary dysfunctions in the cholepoietic system. The studies indicated that baseline high PGE1 levels and slow increases in PGF2 alpha during vesical reflex might be one of the factors predisposing to biliary hypokinesia. In patients with Oddi's sphincter spasms, the period of active PGE1 synthesis coincides with that of sphincter spasm. It is suggest that the latter is due to PGE1-induced muscle spasm of the duodenum whose fibers are an integral part of the intricate muscle system of Oddi's sphincter. In Oddi's sphincter spasm concurrent with biliary dyskinesia, the curve of PGF2 alpha virtually little differs from that in Oddi's sphincter spasm alone. PGE1 increases at the closed sphincter stage in the same way as that elevates in isolated sphincter spasm, but in patients with biliary hypokinesia contaminant with Oddi's sphincter spasm PGE1 shows its concentration in the vesical reflex phase, which appears to result in biliary hypokinesia. PGE1 and PGF2 alpha imbalance is one of the links in the pathogenesis of biliary dyskinesia.

[Evaluation of pulmonary hypertension by dopplerography in patients with nonspecific pulmonary diseases]. / Otsenka gipertenzii malogo kruga krovoobrashcheniia u bol'nykh nespetsificheskimi zabolevaniiami legkikh metodom dopplerografii.

Doppler echocardiography was used to quantify pulmonary hypertension and phase pattern of right heart systole in 140 patients with nonspecific pulmonary diseases to study hemodynamic characteristics of pulmonary circulation and right heart as well as external respiration. There appeared a relationship between the severity of pulmonary hypertension, bronchial obstruction and arterial hypoxemia. It seems that in nonspecific pulmonary diseases hemodynamic changes arise prior to functional disorders of external respiration.

[Characteristics of external respiration function and pulmonary circulation in patients with ischemic heart disease complicated by disorders of intraventricular conduction]. / Osobennosti funktsii vnechnego dykhaniia i legochnogo krovotoka u bol'nykh ishemicheskoi bolezn'iu serdtsa, oslozhnennoi narusheniiami vnutrizheludochkovoi provodimosti.

The authors provide evidence on the condition of external respiration and hemodynamic shifts in the lesser and greater circulation in coronary patients with bundle-branch block; establish early objective quantitative criteria of the diagnosis of hemodynamic impairment arising in formation of the above blocks basing on ECG, phonocardiography, echocardiography findings; compare hemodynamic effects of single-dose nitrosorbide and corinfar in the above patients. Nitrosorbide and corinfar correct hemodynamics and external respiration, the former being more effective in normalizing the greater, while corinfar the lesser circulation.

[The possibilities of using intermittent normobaric hypoxia for treating hypertension patients]. / Vozmozhnosti ispol'zovaniia preryvistoi normobaricheskoi gipoksii dlia lecheniia bol'nykh gipertonicheskoi bolezn'iu.

The response to intermittent normobaric hypoxia (INH) created in breathing gas hypoxia mixture (10% oxygen, 90% nitrogen) was evaluated in 123 patients with essential hypertension stage I and II. Hypoxia adaptation effects on central hemodynamics, physical performance, kinetics of oxygen exchange were studied. A pronounced response to INH persistent for 6 months was demonstrated in 80.5% of the patients. The reduction of the arterial pressure resulted from different mechanisms depending on hemodynamic type. Physical performance of the patients rose, oxygen consumption and transport normalized.

[The evaluation of the efficacy of adaptation to intermittent normobaric hypoxia as a method for treating hypertension]. / Otsenka éffektivnosti adaptatsii k preryvistoi normobaricheskoi gipoksii kak metodu lecheniia gipertonicheskoi bolezni.

Clinical and functional condition was examined for 75 patients with essential hypertension stage I and II who had developed adaptation to normobaric cyclic-fractionated hypoxia. The latter was produced by gas hypoxic mixture (10% oxygen, 90% nitrogen) in its inhalation. A pronounced positive effect of such treatment modality was registered in 86.7% of the patients and persisted for 6 months and more in 84.3%. A normal correlation was achieved of cardiac ejection to peripheral vascular resistance, this reducing arterial pressure. An optimal hemodynamic response arose to the hypoxic effects which also improved psychoemotional status of the patients.

[The correction of motor-tonic disorders of the gastrointestinal tract and of duodenogastric reflux with laser radiation]. / Korrektsiia motorno-tonicheskikh narushenii zheludochno-kishechnogo trakta i duodenogastral'nogo refliuksa lazernym izlucheniem.

Forty-five patients with duodenogastric reflux and defective gastroduodenal motor tonicity (gastroduodenal hypotonia, duodenal hypertension, gastric hypotonia in combination with duodenal hypertension) were exposed to He--Ne laser radiation. The impact was focused on the biologically active points G14, TR5, VC15, E21. The treatment resulted in normalization of the gastrointestinal pressure gradient, in discontinuance or reduction of duodenogastric reflux.

[Cardiorespiratory disturbances in atrioventricular block]. / Osobennosti kardiorespiratornykh narushenii pri atrioventrikuliarnykh blokadakh]

The paper covers questions of the emergence and progressing of cardiorespiratory disturbances in coronary patients with defective atrioventricular conduction. The authors characterize central and peripheral hemodynamics in the above patients, diastolic ventricular filling, external respiration, the disturbances of which were studied in correlation with hemodynamic features and lipid peroxidation. The patients were examined for effects on their cardiorespiratory system of cardioselective beta-blockers, adrenomimetics, antioxidants, membrane stabilizers.

[A comparative evaluation of the hemodynamic effects of nitrosorbide, korinfar, obzidan and spesikor in blockade of the left branch of the bundle of His]. / Sravnitel'naia otsenka gemodinamicheskikh éffektov nitrosorbida, korinfara, obzidana i spesikora pri blokade levoi nozhki puchka Gisa.

The paper deals with hemodynamic parameters in the greater and lesser circulations in patients with CHD concurrent with left bundle branch block. Based on the results of clinical and instrumental studies involving electrocardiography, phonocardiography and echocardiographic techniques, the authors provide early objective measures for diagnosing the hemodynamic changes occurred with development of left bundle branch block. The authors make a comparative assessment of hemodynamic effects produced by single administration of nitrosorbide, corinfar, obsidan, and spesicor in the patients examined. Nitrosorbide and corinfar improve left ventricular contractility, reduce the degree of pulmonary hypertension and right cardiac overload, while obsidan and spesicor aggravate the hemodynamic changes in patients who have CHD and left bundle branch block.

[Adaptational reactions in patients with acute pneumonia]. / Adaptatsionnye reaktsii u bol'nykh ostroi pnevmoniei.

Adaptive reactions were studied in 80 patients with acute pneumonia. In the hospital 94.1% patients showed reactions of stress and incomplete reactions of training and activation. With improvement of the clinical condition the number of stress reactions reduces, while the number of physiological reactions of training and activation increased. The stress reaction is an unfavourable factor as to transition of acute pneumonia into chronic unspecific pulmonary diseases. These studies may be of value for evaluation of the prognosis and care of acute pneumonia.

[The function of the left heart in blockade of the left bundle of His]. / Funktsional'noe sostoianie levykh otdelov serdtsa pri blokade levoi nozhki puchka Gisa.

A complex Doppler echocardiographic study was performed in 134 patients with complete block of the left bundle branch, its anterior branch or with concurrence of these two types of intraventricular conduction disturbance. The authors identified 5 types of paradoxical ventricular septal motion, which were related to the specific features of intraventricular asynchronism and ventricular electric systole. Type I shows the greatest decrease in left ventricular contractility, left atrial overload and phasic destruction of left ventricular systole, which reflects the processes of depolarization and repolarization propagation in the myocardium. Type IV is characterized by the lowest number of hemodynamic abnormalities. Cardiac hemodynamics is also related to the type of intraventricular block, being the least changed in isolated anterior left bundle-branch and the most changed in concurrent anterior branch and entire left bundle-branch block.

[The correction of functional disorders of the bile-secreting system by using laser radiation]. / Korrektsiia funktsional'nykh narushenii zhelchevyvodiashchei sistemy s pomoshch'iu lazernogo izlucheniia.

He-Ne laser irradiation of biologically active points and infrared laser irradiation of the liver were employed to improve gallbladder and sphincter functions, bile production and biochemistry, respectively, in a total of 57 patients with biliary dyskinesia presenting as hypokinetic dyskinesia of the gallbladder, hyperkinetic dyskinesia of the sphincter of Oddi or the combination of the two affections. Simultaneous use of the two kinds of laser irradiation appreciably shortens treatment duration, abolishes biliferous dysfunction, reestablishes physiological balance of bile components in case of its initial lithogenic potential.