RESUMO
There are presented results of photodynamic therapy (PDT) for patients with chemo- and radioresistant intradermal metastases of breast cancer using the matrix light-emitting diodes apparatus. To all patients prior to irradiation there was performed fluorescence diagnostics to assess the accumulation of the photosensitizer of chlorine series and photobleaching during PDT. The size of the irradiation area was 400 sm, the total dose of irradiation was 250J/cm2. PDT was accompanied by mild pain, which was stopped by administration of non-narcotic analgesics. Complete regression of intradermal lesions was registered in 2 of 4 cases, partial response was observed in 1 patient and the progression of the process in 1 case.
Assuntos
Neoplasias da Mama/patologia , Fotoquimioterapia/instrumentação , Fármacos Fotossensibilizantes/uso terapêutico , Neoplasias Cutâneas/tratamento farmacológico , Neoplasias Cutâneas/secundário , Feminino , Humanos , Pessoa de Meia-Idade , Fotoquimioterapia/métodos , Resultado do TratamentoRESUMO
Cancer stem cells (CSCs) possess self-renewal and heterogeneous cancer cell lines formation. Numerous data confirm the existence of a model in which CSCs have an important role in cancer initiation, progression and clinical outcome. Analysis of CSCs role in metastasis, in contrast, remains mainly conceptual and hypothetical. Recent data are summarized in this review which support the CSCs theory as a source of breast cancer metastatic lesions with noting the key role of the microenvironment.
Assuntos
Neoplasias da Mama/patologia , Células-Tronco Neoplásicas , Linhagem Celular Tumoral , Progressão da Doença , Feminino , Humanos , Células-Tronco Neoplásicas/patologia , Células Estromais/patologiaRESUMO
Data results of treatment of elderly breast cancer patients in different medical centers are provided, cohort up to 1922 patients. Better survival indicators are recorded within this category when using standard treatment plans (the same as for main category of patients). However it has been noticed that in most cases the patients' age (70-80 years) was considered a barrier to prescription the adequate treatment; 54-98% of patients do not receive standard treatment.
