[An outbreak of Streptococcus zooepidemicus-caused infection among laboratory primates]. / Vspyshka infektsii, vyzvannoi Streptococcus zooepidemicus, sredi laboratornykh primatov.

An outbreak of septicemia caused by S. zooepidemicus in representatives of 5 species of lower monkeys, viz. Macaca mulatta (5), Macaca nemestrina (1), Macaca fascicularis (2), Cercopithecus aethiops (2), Mandrillus sphinx (1), is described. The disease was accompanied by the symptoms of enteric infection and well responded to etiotropic therapy with antibiotics of the penicillin row. The source of this infection was not established. Until now it is one of few descriptions of enteric infection in lower monkeys caused by S.zooepidemicus.

[A comparative study of the immunogenicity of 2 group-B meningococcal vaccines in monkeys]. / Sravnitel'noe izuchenie immunogennosti dvukh meningokokkovykh vaktsin gruppy B na obez'ianakh.

The comparative study of two group B meningococcal vaccines manufactured in the USSR and in Cuba was made. The vaccine manufactured in the USSR contained the noncovalent compound of group B Neisseria meningitidis polysaccharide and outer membrane protein, and the Cuban vaccine contained group B N. meningitidis outer membrane proteins and group C N. meningitidis polysaccharide. The data obtained in this study indicated that both vaccines possessed immunological potency evaluated according to their capacity to stimulate the formation of bactericidal antibodies, whose level was found to increase eightfold after the immunization of monkeys in two injections. Besides, group B meningococcal vaccines did not induce the suppression of nonspecific protective activity characteristics of the body and did not stimulate the formation of autoantibodies to brain and liver tissues, which was indicative of the safety of these vaccines.

[Immunological status of monkeys during acclimatization and its correction with levamisole]. / Immunologicheskii status obez'ian v protsesse akklimatizatsii i korrektsiia ego levamizolom.

The work presents the results of investigations, carried out in different monkey species, on the physiological norms as regards the bactericidal factors of neutrophilic polymorphonuclear leukocytes in the blood, nonenzymatic lysosomal cationic proteins and myeloperoxidase, as well as on changes in these characteristics in monkeys at different periods of their acclimatization at the Institute of Experimental Pathology and Therapy, Sukhumi. The possibility of correcting the characteristics under study by means of the immunostimulating agent levamisole is shown.

[Dynamics of lysosomal cationic proteins in experimental streptococcal infection in monkeys]. / Dinamika lizosomal'nykh kationnykh belkov pri éksperimental'noi streptokokkovoi infektsii u obez'ian.

The study of the time course of nonenzymatic lysosomal cation proteins in monkeys (rhesus macaques) revealed its correlation with the clinical manifestations of the developing disease. At the period of pronounced clinical manifestations of the disease the cation protein indices decreased. They returned to the initial level when the general state of the animals improved, the erythrocyte sedimentation rate decreased and the leukocyte formula became normal. The determination of the cation protein level can serve as an additional test for the evaluation of the natural resistance of the body.

[Pathologic anatomy of experimental diseases of small laboratory animals caused by encephalomyocarditis virus (strain EMK-70)]. / Patologicheskaia anatomiia éksperimental'nogo zabolevaniia melkikh laboratornykh zhivotnykh, vyzvannogo virusom éntsefalomiokardita (shtamm EMK-70).

The results of pathomorphological investigation of the disease in small laboratory animals experimentally induced by the EMC-70 strain of encephalomyocarditis virus isolated from monkeys are presented. Irrespective of the mode of virus injection, the newborn and juvenile mice developed some lesions in the brown fat, transverse-striated muscles, as well as in the brain and heart. In guinea pigs the changes were characterized by the development of severe myocarditis and encephalitis accompanied by viral antigen accumulation. The disease induced by the EMC-70 strain could not be differentiated from the Coxsackie infection by the pathomorphological data. This fact should be taken into consideration in solving some problems pertinent to pathoanatomical diagnosis of viral diseases.

[Immunological efficacy of live streptomycin-dependent salmonellae vaccines used orally in experiment on monkeys]. / Immunologicheskaia éffektivnost' zhivnykh streptomitsinzavisimykh sal'monelleznykh vaktsin pri peroral'nom primenenii v éksperimente na obez'ianakh

Experiments were conducted on 99 monkeys; a study was made of the reactogenic properties and the immunological efficacy of the streptomycin-dependent S. enteritidis and S. typhimurium mutants in oral application. The results of clinical, bacteriological, pathomorphological and fluorescent-serological studies demonstrated that the vaccines in the doses under study were areactogenic for monkeys in 5-fold oral administration and promoted development of marked immunity. The greatest immunizing effect was obtained in 5-fold oral vaccination with the subsequent three-fold (in 2 months) revaccination of the monkeys. Associated streptomyqin-dependent S. enteritidis and S. typhimurium vaccine could be used for prophylaxis of salmonellosis in monkeys.