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3.
Eur Ann Allergy Clin Immunol ; 45(3): 113-5, 2013 May.
Artigo em Inglês | MEDLINE | ID: mdl-23862403

RESUMO

This study reports an unusual case of repeated anaphylactic episodes to orange and apple without clinical evidence of primary sensitization to peach LTP. In vitro and in vivo tests revealed heat stability of the implicated allergens and also provided new evidence of differences in allergenicity among apple varieties and strong cross reactivity of citrus fruits. "Prick-to-prick" method with fresh fruits proved to be a quick and advantageous tool in investigating allergy to fresh fruits.


Assuntos
Anafilaxia/etiologia , Citrus sinensis/imunologia , Hipersensibilidade Alimentar/etiologia , Malus/imunologia , Proteínas de Transporte/imunologia , Reações Cruzadas , Humanos , Masculino , Pessoa de Meia-Idade
14.
Allergy ; 56(7): 653-9, 2001 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-11421924

RESUMO

BACKGROUND: Mizolastine, a potent H1 antihistamine with additional antiallergic properties, is marketed for the treatment of allergic rhinoconjunctivitis and urticaria. The objective was to investigate the safety and effectiveness of mizolastine under conditions of daily practice in patients with seasonal allergic rhinoconjunctivitis (SAR). METHODS: In an open multicenter study, mizolastine 10 mg daily was administered for 14 days during the pollen season. Nasal and ocular symptoms, time to onset of symptom relief, and effect of the drug on diurnal alertness were evaluated. Safety was evaluated on the basis of self-reported adverse events (AE). RESULTS: A total of 5408 patients (36+/-14 years of age, females=57%) with a history of SAR for 8+/-9 years were treated for a mean of 17.1+/-5.0 days. SAR symptoms improved in 93% and decreased by at least 50% in 86% of patients; 78% reported improvement after the first drug intake and 51% from the first hour. Sixty-nine percent considered mizolastine more effective than other antihistamines taken previously. The incidence of AE was low (3.8%). CONCLUSION: The high responder rate, the rapid onset of action, and the low incidence of AE observed in this large multicenter study confirm the previously reported beneficial efficacy and safety of mizolastine in the management of SAR.


Assuntos
Conjuntivite Alérgica/tratamento farmacológico , Antagonistas dos Receptores Histamínicos H1/uso terapêutico , Rinite Alérgica Sazonal/tratamento farmacológico , Adolescente , Adulto , Benzimidazóis/efeitos adversos , Benzimidazóis/uso terapêutico , Criança , Estudos de Coortes , Conjuntivite Alérgica/epidemiologia , Europa (Continente)/epidemiologia , Feminino , Antagonistas dos Receptores Histamínicos H1/efeitos adversos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Rinite Alérgica Sazonal/epidemiologia , Resultado do Tratamento
15.
Allergy Asthma Proc ; 20(2): 107-8, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10209687

RESUMO

The existence of professional allergens in the home environment is important because their avoidance usually resolves the problem completely. We report on a case of an asthmatic woman who, for five years, was helping her husband create large artistic screens with the cocoons of the silkworms. Extensive laboratory evaluation revealed that she was allergic to silk and her symptoms resolved in three months following discontinuation of her exposure to silk allergens.


Assuntos
Asma/etiologia , Proteínas de Insetos/efeitos adversos , Adulto , Animais , Asma/sangue , Bombyx , Feminino , Humanos , Imunoglobulina E/sangue , Teste de Radioalergoadsorção , Seda , Testes Cutâneos
16.
Allergy Asthma Proc ; 20(1): 15-22, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10076705

RESUMO

A comparison of the date of birth of 1501 adult patients with severe seasonal respiratory allergy (allergic rhinitis or bronchial asthma) due to parietaria, olive, and grass pollens with the expected births within 2,020,420 births in South Greece during the same period, was performed. The relative risk for developing respiratory allergy was characteristically increased in those born in a specific period of time different for each pollen. The relative risk for parietaria was increased (1.47) in those born in March; for olive it was 1.6 for May; 1.2 for April; and 1.4 for March, while the relative risk for grasses was 1.2 in those born in June and July. These findings are indicative of the importance of the month of birth; that is, the early exposure to pollens, for the development of respiratory allergy to certain pollens during adulthood. Because our findings do not directly correlate completely with the aerobiology studies on pollen calculation in Athens' atmosphere, we supposed that other environmental factors, e.g., the local intensity of the first pollination or the influence of weather conditions, may contribute to the final development of respiratory allergy as well. The most impressive finding was the significant influence of the month of birth in the development of respiratory allergy due to parietaria and olive pollens during adulthood.


Assuntos
Asma/epidemiologia , Pólen/imunologia , Rinite Alérgica Sazonal/epidemiologia , Estações do Ano , Adulto , Asma/imunologia , Intervalos de Confiança , Coleta de Dados , Feminino , Grécia/epidemiologia , Humanos , Incidência , Masculino , Análise Multivariada , Testes do Emplastro , Pólen/efeitos adversos , Gravidez , Rinite Alérgica Sazonal/imunologia , Fatores de Risco , Fatores de Tempo
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