RESUMO
Most clinicians consider duodenum ulcer as a psychosomatic disease. Objective: To show the interdependence of this condition and mental disorders and their relation to disturbances of melatonin production . Materials and Methods: 15 patients with seasonal DU and 15 healthy subjects of the control group were examined during 3 years using laboratory, endoscopic, and standard psychodiagnostic methods. Results. It was found that all patients with exacerbation of DU experienced enhanced anxiety, reduced background mood, and impaired quality of life based on general health and mental health scoring scales. The circadian rhythm of melatonin production was markedly distorted throughout the observation period but especially during exacerbations of the disease. Conclusions. The results indicate a high degree of correlation between DU and mental disorders caused by impaired production of melatonin. It suggests common etiological mechanisms of DU and psychosomatic symptom complex.
Assuntos
Ansiedade , Depressão , Úlcera Duodenal , Melatonina , Transtornos Psicofisiológicos , Qualidade de Vida , Ansiedade/diagnóstico , Ansiedade/fisiopatologia , Fenômenos Cronobiológicos , Ritmo Circadiano , Depressão/diagnóstico , Depressão/fisiopatologia , Úlcera Duodenal/diagnóstico , Úlcera Duodenal/fisiopatologia , Úlcera Duodenal/psicologia , Duodenoscopia/métodos , Feminino , Humanos , Masculino , Melatonina/análise , Melatonina/biossíntese , Pessoa de Meia-Idade , Testes Psicológicos , Transtornos Psicofisiológicos/diagnóstico , Transtornos Psicofisiológicos/metabolismo , Transtornos Psicofisiológicos/fisiopatologia , Estatística como Assunto , Inquéritos e QuestionáriosRESUMO
UNLABELLED: OBJECTIVES. This work was designed to study melatonin (M) production levels in duodenal ulcer (DU) patients in the exacerbation and remission stages and in DU patients with a different course of DU in the exacerbation and remission stages. METHODS: DU patients (15 men aged 20 to 45, mean age 34,2 +/- 1,1 years) were studied. The control group included 11 healthy volunteers (men aged 20-45, mean age 32,5 +/- 1,4 years). M was measured by RIA-method using H(3)-labeled M in daily urine collected at 3-hour intervals (8 portions per day). Mathematical processing was carried out using ANOVA, Student's t-test, and cosinor analysis. Differences at p< or = 0,05 were considered to be significant. RESULTS: A strong disturbance of M secretion in DU patients both in the exacerbation and remission stages and a direct correlation between the degree of M production disturbance and severity of clinical course of DU were revealed. CONCLUSION: The obtained results suggest that circadian rhythms of M production are altered in DU patients. M was supposed to be involved in the pathogenesis of DU.
